When reading this article this came to my mind: Shouldn't they also try to find out why these receptors are up- or downregulated? Of course it will make people feel better if the pain or inflammation is reduced (and that's important), but couldn't it be that this is rather fighting the symptoms than fighting the cause of the symptoms? For example, if a virus was causing the problems, couldn't the inflammation be a necessary reaction to at least try to fight the virus, even if not fully successfully? Or couldn't the pain be there because there is some other, underlying problem, like you said here? And stopping the pain would be a good thing, but then going back to full activity might actually lead to damage, because the underlying problem is still there and the body is now functioning at a level that is too much.
I'm only a layman and don't have any qualifications in that area, but unless a dysfunction of these receptors is the cause of ME/CFS, adressing only the receptors would not be the solution, in my limited understanding, or am i missing something? What i find more interesting here is the potential for a biomarker and the possibility to define subgroups.