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Thanks in advance,
Dan
Hi, Dan.
In a person whose cells have normal intracellular B12 processing enzymes, methyl-B12 can indeed be converted to adenosyl-B12. Normally, the various forms of B12 that are absrorbed by the gut enter the cells attached to the carrier molecule transcobalamin, via endocytosis of transcobalamin receptors in the plasma membranes of the cells. One of first things that happens is that the ligand (methyl-, adenosyl-, cyano-, hydroxo-, aquo-, or glutathionyl-) is removed, and the cobalamin is converted to either adenosyl- or methyl-B12 as needed by the cell. If large dosages are taken sublingually, transdermally or by injection, so that the transcobalamin becomes saturated, the excess B12 will be carried in the blood in the unbound state. Apparently, some of this is able to diffuse into cells without benefit of transporters and receptors, and can be used directly by the cells. It is not clear whether B12 that comes in this way can be converted from one form to another. I don't think that has been studied.
Rich
Thanks Rich and Fred,
I appreciate your replies.
I realize I'm probably not getting 'enough', but as I and others have experienced, I have to start slow. Believe me, I wish I could take high doses right away, but just can't tolerate it.
I almost went with injections, but decided to go with nebulized methyl b12 -- my doc preferred the methyl -- as I've been having the same problem as others with the sublinguals: Tooth and oral pain after about a week or so of starting them (both the Jarrow mb12, and the Source Naturals Adb12) -- and that was with 1/4 or less tablet pieces. I stopped for 3 days, tooth/mouth pain went away, then started again, and pain came back (felt like a cavity flaring) within a day or two.
I realize nebulizing might not as ideal as injections or sublinguals, but feel like for the moment, I don't have much of a choice, and it's better than nothing. Perhaps to Fred's horror, my doc has added small amounts of glutathione to the nebulizing, to protect the b12 from being hijacked by toxins). My reduced glutathione was very low way back last August, and is no doubt lower now.
Perhaps by mid July I can switch to injections (when I'm "stronger"), and in the meantime, find some other way to get the ad12 in my system at higher doses. Suggestions are always appreciated.
Thanks to you both for your input -- very much appreciated as always.
d.
Hi Dan,
An alternative method of using taking a sublingual Source Natural Adb12 or mb12 for that matter that would likely work well but more slowly, would be rectal. Absorption tends to be quite high but takes hours longer. Do you brush and floss your teeth daily? If you don't floss daily you will have inflammation, harbor infection and have gum bleeding when brushing is quite possible.