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Yes, probably he said IgG. I understood IgC, but the sound is not very clear at this point, and since IgC antibodies don't seem to exist (did a quick google search just now), i guess it's IgG.
What i also like, i think he said they want to isolate infectious viruses to find out how the virus replicates and what it does to the [immune?] system.
Yes, i think no matter what happens, we will probably have to get active and make sure there's enough money in this research. I guess if XMRV is validated, there will be much more "government" money, but nevertheless, there can probably never be enough funds in something like this, so we should pour in as well.The good thing is that there are so many legit virologist and immunologist involved now that whatever the verdict turns out to be..it will probably actually be the truth... I just hope when/if they discover XMRV is not the "be all" for M.E. that all these talented people and $$ don't fade out like they did after the last retroviral detection of the early 90s.
Re: IgG: Thanks for the follow up. I would guess its IgG and probably a subclass within IgG but with science ever evolving its hard to know... they could have renamed something IgC.
Moreover, the new retrovirus XMRV seems to have originated in a leap from mouse to humans. Although at first XMRV infection was associated with prostate cancer and chronic fatigue syndrome, the results of international research groups have confirmed the role of human pathology XMRV permanently.
In any case, experts say there are "major problems" for the diagnosis of infection XMRV and still unaware of many aspects of the biology and transmission of this virus. However, fear has been raised in the United States have been excluded from blood donation in patients with chronic fatigue syndrome.
A total of 1,144 persons with HIV infection rare
The National Register of infection detected in 2010, a total of 39 new cases in Spain of HIV-2, HTLV-1 and HTLV-2
MADRID, Dec. 11 (EUROPA PRESS) -
A total of 1,144 people in Spain suffer human retrovirus infections than HIV-1, the principal agent of AIDS, as HIV-2 or HTLV-1 and HTLV-2, which together have added 39 new cases 2010, according to latest figures of the Spanish Group for the study of human retrovirus infections than HIV-1, which celebrates the 15th December at the Hospital Carlos III of Madrid the XXI Annual Meeting.
The group belongs to a network of 40 hospitals and research centers belonging to the National Health System (SNS), under the direction of Dr. Vincent Soriano, Service of Infectious Diseases, Hospital Carlos III, responsible for the National Register of infection HIV-2 and HTLV since its creation in 1989.
According to this record, so far 244 cases have been reported in HIV-2 infection in Spain, of which 163 are men, mostly infected through heterosexual sex and 10 percent co-infected with HIV-1.
The new cases identified in 2010 added 24 and the majority are immigrants from sub-Saharan Africa. However, four new cases have been described in native Spanish, and although the majority of new cases were asymptomatic, two of which the presentation was a lymphoma.
For his part, during 2010 have been reported 13 new cases of HTLV-1 infection in Spain with the national registry collects 175 cases. All cases diagnosed in 2010 are immigrants from Latin America, except a Spanish woman who presented with tropical spastic paraparesis. One of their sexual partners was in Ecuador and, despite remaining asymptomatic, was diagnosed after infection with HTLV-1.
Regarding the number of cases of infection with HTLV-2 accumulated in Spain the figure is 725. It is mostly in Spanish, many with a history of using intravenous drugs. For this reason, experts point out, many are co-infected with HIV-1 and chronic hepatitis C sufferers.
In this regard, in 2010 identified two immigrants have been infected with HTLV-2, one from Ghana and one from Brazil. Both are asymptomatic and probably acquired the infection from sex, says the record.
MUTATIONS FROM PRIMATES AND MOUSE
As for the new human retrovirus described in recent years, experts agree that its origin is in jumping from species of primates to humans in West Africa. This would have described two new HTLV, called HTLV-3 and HTLV-4, and a new variant of HIV-1 group called P.
In Spain have not been identified so far infected with these retroviruses, mainly from Cameroon and neighboring countries, including Equatorial Guinea, a former Spanish colony.
Moreover, the new retrovirus XMRV seems to have originated in a leap from mouse to humans. Although at first XMRV infection was associated with prostate cancer and chronic fatigue syndrome, the results of international research groups have confirmed the role of human pathology XMRV permanently.
In any case, experts say there are "major problems" for the diagnosis of infection XMRV and still unaware of many aspects of the biology and transmission of this virus. However, fear has been raised in the United States have been excluded from blood donation in patients with chronic fatigue syndrome.
BREASTFEEDING, main route of transmission of HTLV
During the meeting also presented the results of epidemiological studies of HTLV made by the group in recent years. In the case of pregnant women, breastfeeding is the main route of HTLV transmission to the newborn.
In this regard, the HTLV test performance as evidence of "ante-natal" in more than 2,500 pregnant foreign residents in Spain has identified seven cases, all in Latin American pregnant. For this reason, experts stress that "it would be advisable to" make the HTLV test to all pregnant women from endemic areas, mainly in Latin America.
For two years, many blood centers have begun screening for HTLV in blood donors from endemic areas. In this way, and throughout 2010, Madrid have been identified in nine cases of infection with HTLV-1 and two HTLV-2.
For its part, the transfusion center of Catalonia, where it becomes the universal screening of all donors HTLV, only in 2010 have identified four cases of HTLV-1 infection in two Spanish and two Latin American as well A case of HTLV-2 infection.
data collected in the study suggest that B cells may represent a reservoir for retrovirus XMRV and contribute to its pathogenicity. The data also show that the histological study of human lymphoid tissue is a suitable model for analyzing the pathogenesis of XMRV.
Studies of B cells, T and NK cells suggests a (global) immune dysfunction of unknown cause as a potential contributor to the mechanism of development of CFS.
(tonsil are lymphoepithelial tissues) ineresting is the part about EBV and the article i posted before on EBV and infected Bcells)confirms the effectiveness of XMRV to infect in vitro and in vivo lymphocyte cells such as B lymphocytes As a new (hypothesis?), state that Epstein Barr virus act as a "gateway" of XMRV in B cells that act as "reservoir" (the place where most viruses accumulate) of the disease
OMG, Aruschima!!!! We will have to talk about that later, it's very interesting and it's cool to meet someone from Switzerand here (even though i prefer Canada as my home country, but i lived far more time in Switzerland). Just now i'm very stretched, i have to travel to Barcelona tomorrow and then catch the nighttrain. Now have to find a post office that's still open, so i can send a parcel and don't have to carry all the baggage...Eric, I just saw that you are also from Switzerland, although living in Asia.
About joining different groups;choices in Switzerland are limited, to say the least , and the one we have is an awful patient organisation linked to 2 psycho-somatic docs, who dictate the whole false information spread in our country and make wrong DX's ! I made the mistake and joined them years ago (before I knew anything about about CFS) and now I have a false diagnosis by a psychologist in my files, because he tricked me saying he has to file it under psycho-somatic for insurance purposes. (But he acted and spoke like he believes it is a real disease. A trick they use very often, facing "difficult" patients) Very difficult to get rid of that; which is now, since they are changing the disability system a night mare, although I was diagnosed in the mean time by Meirleier and have test which show all the biological immune abnormalities and activated viruses)
So much for joining groups.