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niacin and D ribose

wallace

Senior Member
Messages
107
It seems to me an agressive niacin protocol going up to 6000mg in divided doses daily is worth trying. Obviously with lots of detox, vit c etc.

Wallace

Here is an extract from a blog

had tried lots of different supplements for CFS, as recommended by various people. For example, Dr. Sarah Myhill recommends a supplement protocol for treating CFS, which she nicked from cardiologist Dr. Stephen Sinatra, which includes co-enzyme Q10, L-carnitine, niacin, D-ribose and magnesium. (Sarah Myhill writes: "acetyl L-carnitine [is] also available through eating red meat, especially mutton, lamb, beef and pork - but to get 2 grams you need to eat about a pound of meat a day!" Who would be so crazy as to a eat a pound of meat per day?! Har har har!) With every supplement I used the question "Does this occur naturally in meat?" as a rule of thumb to determine whether I needed a supplement, because I disagreed with some of supplements people recommended, such as megadoses of vitamin C, which are not natural in a carnivorous diet. As carnitine, Q10, and niacin (also from tryptophane, and in


beef liver) are all found in large amounts in an all-meat diet, I had started using Q10, L-carnitine, and a B-complex from Puritans Pride, among other things. Because ribose does not occur in meat (except in trace amounts), and because it is a carbohydrate, I avoided it.

My chronic fatigue syndrome somehow got better after a few months of zero-carb, but strangely, the maldigestion problems got worse and worse by order of magnitude (I don't have an explanation for this). Zero-carb didn't help me in this regard at all. After months of physical torture, the maldigestion thread on ZIOH finally helped me to figure out I needed HCl.

After a while I figured out that I could take as much as 70 betaine HCl capsules per meal without problems; 80 to 100 caused stronger burning sensations of varying degrees of strength. The most I ever took was 144 (don't ask...). I could swallow 20 capsules on an empty stomach without feeling anything. Recall that the pH scale is logarithmic (with base 10): multiplying the concentration of HCl [by a factor of 10] decreases the pH by 1 point. A 5% solution of betaine HCl is approximately 8 tablets of 648 mg dissolved in 100 ml water. If it is the case that a "5% solution of Betaine HCl has a pH of 1", then 80 capsules have a pH of 0. As a reference point, the pH of an empty stomach is about 1, like a car battery, and food buffers the acidity by about 2-3 pH points upward.

But what is truly more insane is that the gastroenterologist literaly said "I don't believe you have hypochlorhydria"! Both gastroeterologists I visited did not even know what hypochlorhydria was, and didn't test for it; So much for specialists! I could not believe it, but it was just like Dr. Jonathan Wright describes in his excellent book: stomach pH testing and supplemental HCl has fallen in disrepute among doctors apparently because pharmaceutical companies make millions of profit from stomach acid inhibitors.

[continued]

At 8/03/2010 2:34 PM, Anonymous The Plague Doctor said...

In the past months, I have been reading all the books and web sites on hypochlorhydria I could get my hands on. As I almost died from malnutrition before I figured out what was going on, hypochlorhydria has (unfortunately) become of the utmost importance to me (as you can imagine). I became way too fatigued to participate in any forum discussions but I was avidly reading everything. That's when I stumbled upon these series of articles by Dr. Jonathan Prousky (1, 2, 3).

These articles implicate mitochondrial dysfunction as the cause of hypochlorhydria. Since my stomach problems really worsened after I got CFS, and mitochondrial dysfunction is suspected to be the cause of CFS, I (belatedly) decided to resume the ENTIRE recommended supplement protocol for CFS, this time including megadoses of nicotonic acid AND ribose (plus a good B-100 complex): I started using 3 g of nicotinic acid spread throughout the day as well 20 g of ribose spread throughout the day.


Also see this thread on Niacin treating infections:
http://www.healingwell.com/community/default.aspx?f=30&m=1255322