• Welcome to Phoenix Rising!

    Created in 2008, Phoenix Rising is the largest and oldest forum dedicated to furthering the understanding of, and finding treatments for, complex chronic illnesses such as chronic fatigue syndrome (ME/CFS), fibromyalgia, long COVID, postural orthostatic tachycardia syndrome (POTS), mast cell activation syndrome (MCAS), and allied diseases.

    To become a member, simply click the Register button at the top right.

Why Herxheimer reactions are worse at night

I've never seen this published but I find that Herxheimer reactions always increase in intensity as cortisol levels drop in the afternoon. This is for to the same reason that stress causes ME-stress also increases cortisol which suppresses the painful Hirscheimer inflammation.


I've also read somewhere that liver detox ramps up at night as well so maybe that's a part of it too. ???
Small amount of cortisol actually increases the level of inflammation from toxins - large amount indeed suppress; also normally(in relatively healthy beings) melatonin suppress inflammation by a lot but its release becomes largely inhibited by raised toxins/inflammation.

Blog entry information

Read time
1 min read
Last update

More entries in User Blogs

More entries from gbells