There have been lots of changes. I discovered another active supplement that unblocks another block in the apoptosis pathway and added a new herb to the regimen. That one plus caffeine really sped it up. The galvanic stimulation turned out to not be as helpful as I thought. Basically I don't think it's worth the trouble given the expense of the units and limited coverage and penetration. It is better to focus on exercising the areas and treating them with the apoptosis supplements. What I was seeing was that despite galvanic stimulation many areas wouldn't apoptose. Granted they are old infected areas (ribs, feet), I was symptomatic back to 2008 so these will be the hardest to treat. Lots of trial and error. Still, I'm making better progress now. Hopefully this will finish the program. Oh and the nicotine caused chronic hypertension and I learned that most of the hypertensives block apoptosis (the physician was clueless) but I was able to find one that wasn't incompatible, Bystolic.