Treating depression at the microbiome level (diet, probiotics, etc)

I have done a few posts on depression over the years
A friend asked me to revisit it, especially now that I have a recommendation program working.

Depression and the Microbiome – PubMed
From The role of microbiota in the pathogenesis of schizophrenia and major depressive disorder and the possibility of targeting microbiota as a treatment option [2017].

  • over-presentation of the orders of Bacteroidales and
  • under-presentation of the orders of Lachnospiraceae,
  • Higher level of Oscillibacter and Alistipes had higher depression
  • increased levels of Enterobacteriaceae and Alistipes
  • reduced levels of Faecalibacterium
Altered fecal microbiota composition in patients with major depressive disorder [2015]. adds that “Bacterial diversity was significantly higher ” and also reported additionally (for two types of depression):

  • higher Bacteroidaceae,
  • higher Butyricimonas,
  • higher Clostridium XlVb
  • higher Enterobacteriaceae,
  • higher Parabacteroides,
  • higher Phascolarctobacterium,
  • higher Porphyromonadaceae,
  • higher Rikenellaceae
  • higher Roseburia
  • higher Acidaminococcaceae,
  • higher Flavonifractor,
  • higher Proteobacteria
  • lower Actinobacteria
  • lower Fusobacteria,
  • lower Ruminococcaceae,
  • lower Veillonellaceae
  • lower Lachnospiraceae,
  • lower Dialister,
  • lower Escherichia/Shigella,
  • lower Firmicutes,
  • lower Haemophilus,
  • lower Prevotella,
  • lower Ruminococcus
Additionally, Isovaleric acid in stool correlates with human depression.[2016] hence isovaleric acid producing bacteria appear to be another facet.

Isovaleric acid producing bacteria includes [ref]:

  • Bacillus subtilis natto
  • Prevotella
  • Porphyromonas
Automated Analysis of your Ubiome
After you logged on to This Depression link will show your results against the above list. As a reminder, there are other comparisons available:

The result is a report such as shown below

At the bottom is a link to recommendations for the ‘Match’ items above only. That is, the recommendations are specific to the depression symptom.

For the first one on the list, I did a google and found lots of pages saying that pomegranate helps depression!

Imagine that! With the microbiome approach, you are getting truly individualized suggestions and not proforma suggestions.


In a significant percentage of people it should. There can be multiple causes (including DNA).
In a significant percentage of people it should. There can be multiple causes (including DNA).

Blog entry information

Last update

More entries in User Blogs

More entries from Lassesen