Transmission, Remission and Outbreaks, Oh My!

There has been a lot of questions about how a retroviral model would fit in to the world of ME/CFS lately. Could it be responsible in outbreak situations and could it go into remission from time to time, and what would be the mode of transmission if it does both of those?

I've been laying here in 'flare up' misery for a couple of weeks now and my brain has been stirring the pot on those very questions. Considering the fact that I don't have a PhD in Microbiology and I am in the middle of flare take what my brain has come up with, with a large dose of salt. (grins) Now that the caveat is out of the way, forward ho.

First of all let's revisit transmission. We know for a fact that somewhere in the vicinity of 3% of the worlds population is infected with XMRV. [1, 2] Doing the math that means somewhere in the neighborhood of 200 million infected people, of the 200 million infected 17 million or about 8.5% are diagnosed with ME/CFS. Some of us are from outbreaks that are known and reported. Some of us consider ourselves to not be part of the outbreak set. I'm not sure this is true. I know I about fell on the floor when I read that the San Antonio, Texas area had an outbreak between 1970 and 1973. [3] That doesn't come up in many places in the well known literature. So how would someone know if their area had an outbreak and how would someone know if there was an outbreak until 1. well after the fact and 2. if and only if a doctor reports it and it gets written down somewhere and that somewhere gets brought to your attention in reading material. In other words a lot of planets would have to align to really know if you are part of outbreak or not.

So what are the percentages of people actually affected in a cluster outbreak? If say 3 percent of the population of an area were affected that would argue for a direct correlation. And if only 8.5% of the XMRV infected actually end up with ME/CFS then one might make the correlation between percent infected and the percent of those who have some other factor (other than XMRV) that translates from XMRV to ME/CFS. It does make you go hmmm, what else is involved?

My blurry brain says it might look something like this;

XMRV infection (age) + Stress/Cortisol production over life time + Hormone levels/Androgen production specific to individual + Number of Viral infections in lifetime = Sever/Moderate/Light ME/CFS

Which goes back to transmission. When did the person or persons become infected? At birth, this would argue well for the school outbreaks as children tend to be born in clusters. Ever notice how you see one pregnant woman and all the sudden there are twenty more. (grins) If a percent of the women in a town or community are infected then they have a 50% to 75% percent chance of passing it directly to the child [4] and then add to the chance of passing it on via breast milk which adds another 18% [4]

Transmission can happen as a result of blood products used during child hood illness and accidents or later as young people mature and become sexually active. When ever you get the bug it begins the work of replicating.

Replication of a retrovirus is the period when you are most likely to feel or experience symptoms. This is when the virus which is already inserted into a cell will make a copy of itself, release that copy and that copy will go and infect another cell. During this period a lot of things can happen. XMRV can make partial copies and be stopped from complete replication by antiviral mechanisms like APOBEC's, TRIM's [5,6] and RNAse L cellular antiviral protections that are part of our cellular and lymphatic systems. Believe it or not this is actually bad. (grin) partial proteins that get pushed out of the cell and into the system can reek a lot of havoc [7]

For instance, causing an over abundance of certain proteins may make the body stop producing your own version of that protein however the viral protein may not be useable by the body so you end up with a deficit of a particular protein. Viral use of a set of protein building blocks can lead to a reduction of building blocks for other things that the body needs causing a depletion of what would normally use the blocks being used by the virus. The body may try to overcompensate and dump large amounts of a particular protein or building block causing the system to have to work overtime to utilized these building blocks causing problems and back ups in the system. Then there are the building blocks or viral made proteins that get hung out there and reek havoc just by being the wrong thing in the wrong place at the wrong time.

So what caused the virus to replicate in the first place? Well, Reeves and company might have got a small piece of the puzzle right, [8](hey easy with the rotten tomatoes there) stress or cortisol is a major stimulant for XMRV. The more stress in childhood the more XMRV that is made the more cells that are infected along the way. Stress in childhood is likely a predictor of who may end up with full blown ME/CFS in that the amount of cortisol produced in the younger years may lead to an earlier onset and a higher viral load later on. In addition type A personalities produce higher levels or cortisol on a regular basis which could account for the larger percentage of type A people with the illness.

The other factor is androgen production. [9] Men who produce large amounts of testosterone and women who produce large amounts of estrogen are going to need a higher androgen production and hence are more likely if they have XMRV at higher levels. Women who have an earlier onset of puberty may experience higher viral loads as well. Add in the amounts of hormones that women produce on a monthly basis into the replication mix.

In addition to these two replication stimulants there may be (or not) a tendency of XMRV to act in the way that other MLV do and recombine with other MLV's. The replication patterns of other MLV's may be diffrent than XMRV adding yet another possible replication method to the mix. And of course there may well be a problem with oEstrogens which are in all petroleum based products from plastics to medications to foods.

If XMRV is replicating based on cortisol and androgens then some people are going to build up faster when looking at the factors, and slower in others based on the combination. So within a community or group there will be a percentage of persons infected, a percentage of persons who have reached a critical load of XMRV in the system that the bodies antivirals are working hard to keep in check. For the most part without the stimulation from androgens and cortisol the XMRV virus is dormant replicating only in cells that replicate to replace themselves.

Along comes two triggering factors, factor A is the introduction of another virus that takes the bodies systems attention away from XMRV. Factor B is either an androgen spike or cortisol spike and voila you now have a tilted system in favor of XMRV replication and that replication dumps proteins and partial viral strings into the system as your body and the virus duke it out. This is the "outbreak" group. This is the group of people who develop ME/CFS anytime a major virus sweeps through a community. It could be one or two and it could be twenty or thirty with no one really the wiser for it.

However, when you have outbreaks that affect 200 to 500 people or a group of children or a group of nuns then it gets peoples attention. Especially since this is not the usual needle using, risky sex behavior group of people. What was not understood and is only now being seen, is the fact that a very large group of people actually have the virus. (200 million people is nothing to sneeze at) That this retrovirus has been in the population for at least 100 years and that of the group of XMRV infected at least .085% of them will develop ME/CFS either now or at some point in the future.

So what about remission? Can the body actually provide a remission from XMRV? It's quite possible that viral loads can be reduced over a long period of time or a short period of time. Remember two facts. One that XMRV is more or less dormant unless stimulated and that the production of partial virus is what is so hard on the system. On the short period if you have a hard hit of, say, cortisol and/or androgen and an outside virus hits the system, you may get sick short term. If you have a very healthy immune system the hit will come (the worst flu of your life) and go. It may be possible to beat the XMRV back in a short period of time say 6 months to a year, case in point my ex husband became ill and struggled for about a year, then recovered however, not to pre illness levels. However, even if you manage to beat it at the time, the potential to develop full blown ME/CFS is still there. Type B personalities or those with low hormone production are much more likely than a type A personality with more, say testosterone production to be able to beat the virus short term.

So what would have to happen in order to beat this retrovirus in the long term or to experience a remission. For about 20% there is nothing that can be done short of drug intervention. These are the sickest of us who may have low immune systems to begin with and then may have either a constant cortisol production or a level of hormone production that is higher than average. Whatever the factors involved, the system of some patients can not recover on their own.

For the lightly or moderately affected the possibility of recovery may be possible but there are layers that have to be dealt with and each persons layers are different. First you have androgen and cortisol levels that would have to regulated and then layer on top of that problems brought on by protein and partial viral strings that get caught in the system. Those viral strings and proteins begin creating chemical sensitivities and other intolerances. The first layer that has to be delt with before the deeper problems caused by a retrovirus can be addressed if you don't have access to antiretroviral drugs and other drug thearapys. In fact each of us has quite a solar system of planets that will have to align in order to get a remission. The list may look something like this;

1.viral proteins that are causing problems such as celiac disease, mold intolerance and chemical sensitivities have to be address by avoidance most likely for a lifetime or at least until a complete remission.

2. removing outside viral and bacterial hits to the systems. (Course it's hard to ask the spouse to decontaminate upon entering the sterile house and sending the children to boarding school while you get better is kinda hard on the family.) Hopefully antivirals and antibiotics can help to counteract some of the problem but getting these treatments right now is difficult.

3. Revamp your entire personality. If you were a type A or are a "worrier" then you will have to retrain your entire mental and physical system to a type B personality in order to reduce cortisol production on a daily level. And you can never go back to being a type A personality or pushing your system in any way that ups the production of cortisol.

4. anti-hormone products. Which of course will mess with your system in other ways but will reduce XMRV production. (grins)

5. Listen to your body and do what it says. But be able to sort out what is fear from the brain and what is really body signals. Not easy sometimes but doable.

Complete these 5 steps and you could go into a remission and even stay in remission for a good long time. If you have a combination of a few of these steps plus a good immune system remission could happen a lot faster. Most of the anecdotal accounts of remission that I've read have been a combination of taking very good care of the self including giving up the type A way of life and a good immune system or immune boosters.

The take home message in all of this? Yes a retroviral model works for outbreaks and remissions. But there still is no cure or treatment. Until the medical establishment understands this illness as well as we do then there will be no treatment protocols that help us even get to the remission status. Oh, wait we knew all that before. (grins)

[1] Detection of an infectious retrovirus, XMRV, in blood cells of patients with chronic fatigue syndrome.
Lombardi VC, Ruscetti FW, Das Gupta J, Pfost MA, Hagen KS, Peterson DL, Ruscetti SK, Bagni RK, Petrow-Sadowski C, Gold B, Dean M, Silverman RH, Mikovits JA.
Science. 2009 Oct 23;326(5952):585-9. Epub 2009 Oct 8.

[2] Xenotropic murine leukemia virus-related gammaretrovirus in respiratory tract.
Fischer N, Schulz C, Stieler K, Hohn O, Lange C, Drosten C, Aepfelbacher M.
Emerg Infect Dis. 2010 Jun;16(6):1000-2.



[5] Apobec 3G efficiently reduces infectivity of the human exogenous gammaretrovirus XMRV.
Stieler K, Fischer N.
PLoS One. 2010 Jul 23;5(7):e11738.

[6] Susceptibility of xenotropic murine leukemia virus-related virus (XMRV) to retroviral restriction factors.
Groom HC, Yap MW, Galo RP, Neil SJ, Bishop KN.
Proc Natl Acad Sci U S A. 2010 Mar 16;107(11):5166-71. Epub 2010 Mar 1.

[7] Proteins of the XMRV retrovirus implicated in chronic fatigue syndrome and prostate cancer are homologous to human proteins relevant to both diseases.
Christopher Carter1
1. Polygenic Pathways, -
PDF (299.1 KB) Document Type:Manuscript
Date:Received 15 July 2010 01:56 UTC; Posted 15 July 2010


[9] Androgen stimulates transcription and replication of xenotropic murine leukemia virus-related virus.
Dong B, Silverman RH.
J Virol. 2010 Feb;84(3):1648-51. Epub 2009 Nov 11.


Very interesting, George! I shall go and start meditating immediately and get my cortisol permanently down! :D

Thanks for posting - I always like reading your take on XMRV.
Yes, very interesting indeed.
(And I can confirm that getting rid of, or reducing that A type personality really does help).
For treatment suggestions, I strongly suggest people keep track of what their body is telling them, even if they don't always heed its advice. (Mine keeps saying, "drop dead".) I actually kept a journal at one time of what I did, ate or took, and how I felt in the following days. This helped me separate the things which felt good in the short term from those that benefitted me over the long term. Do what works for you, and if things don't work repeatedly, change them. Your doctor may not be any more knowledgable about this illness than you are.

Develop your own personal markers. If you are pushing yourself, and those markers show you going downhill, back off. Ignoring all warnings and constantly 'living on adrenalin' might even burn out your adrenals.

One complicating factor in transmission is a possible latency ranging from zero to years. This makes it extremely difficult to separate cohorts. Very early in the investigation of CFS/ME one researcher found that the people he had used as controls (in the North Carolina Symphony) were coming down with the illness. When he tried to use the Pittsburgh Symphony Orchestra for controls, he discovered one member had come from Carolina. This kind of confounding problem has happened repeatedly.

I suspect outbreaks have apparently stopped in recent years because the infected population is close to equilibrium. Most people who can be easily infected have been.

A second problem is that we don't know which symptoms are the direct result of XMRV and which are due to other infections allowed in or reactivated by immune dysfunction. The variety of manifestations suggests a variety of proximate causes of symptoms. We still don't know if this will hold true all the way back to the initial causes. I tend to think there will be more commonality than is apparent.

Now that we have one thread leading into the maze of CFS (XMRV) I believe it will be possible to make rapid progress. Entire areas of expertise which were previous isolated will be connected.

Finally, prepare to be surprised.

"The problem ain't the things we don't know, it's the things we know that ain't so." Will Rogers
I wasnt able to read that all today (brain is refusing to concentrate for that long), so will try to read it all again another day but i did find your blog interesting in what i did manage to read.

We know for a fact that somewhere in the vicinity of 3% of the worlds population is infected with XMRV. [1, 2] Doing the math that means somewhere in the neighborhood of 200 million infected people, of the 200 million infected 17 million or about 8.5% are diagnosed with ME/CFS.
These figures really interested me as it appears the XMRV may be meeting the same kind of pattern which many other illnesses have with CFS/ME. I remember that something like 10% of ones who get mono end up with CFS/ME, 10% of ones with lyme end up with CFS/ME, 10% of those who get ross river fever end up with CFS/ME, (there was at least one other illness too in which this 10% thing is applying in rates which go on to get CFS/ME) . (i may be about 2% out from what ive read in the past).

So if 8.5% of those who have XMRV end up with CFS/ME .. it seems to be the same kind of pattern of ongoing illness expession going on.

So my mind goes.. what is different about this approx. 10% (give or take two percent either way) .. in the community which on getting sick from one of these things, goes on to get CFS/ME!! If it just a coincidence that this percentage which goes on to get a serious ongoing illness (ME) is about the same?? (it seems a very strange coincidence to me).

There is something to be investigated here.. something about OUR bodies in which any of these things makes it likely for us to get CFS/ME. (and makes it far more likely for us to end up with XMRV???? in the first place????)

Something isnt fitting and i cant work out what.. but this 10% thing of some illnesses leading to XMRV seems more then coincidence. How does XMRV fit into this seeing most of us also are found to have it?
taniaaust1 said:
...Something isnt fitting and i cant work out what.. but this 10% thing of some illnesses leading to XMRV seems more then coincidence. How does XMRV fit into this seeing most of us also are found to have it?
Tentatively assume the hypothesis I've been using, for a moment. If we have two separate 'hits', one infection by XMRV (which generally goes unreported), and the other some immune stressor like another infection, then the percentage of people infected with XMRV will correspond to the percentage of the general population who go on to develop CFS/ME when stressed (physically or mentally, but mostly I mean physical stress). If XMRV has only a minor effect in reducing immune response, and making infection more likely, that rough 10% looks awfully close to the 3% to 7% estimated by Harvey Alter.
thankyou George makes amazing sense everything you said.
stress switching on a retrovirus is a scarey thought but it makes sense. i suffer from stress and anxiety and yep it causes very bad cfs symptoms.
Another superb post, George. I agree with so much of it.

By trial and error I have done much towards points 3 (Revamp your entire personality) and 5 (Listen to your body and do what it says), and it has made my life better.

What I believe might help further is "blanking my brain" more, although it is at times very difficult, and also extremely boring.
Hey guys
Cool reply's I forget to come by check in to see what's being said sometimes so I'm a bit late getting back with a word or two.

4-sasha, big grins, yeah the meditation really does help. I wouldn't have got through this illness without it that's for sure!

4- Victoria, you know about type A personality???? No way!!! (grins) Yeah before I got sick I use to clean the floor on my hands and knees with a rag otherwise it simply wasn't clean. Now I run over it with a vacuum cleaner. (snickers and grins)

4-Daze, when are you going to start bloggin' my man???? You've got a good handle on what's going on. You're way more technical than I am and I think that would appeal to some of the more scientific types on the boards. You should do it man, you're a good writer.

4- SP, Yeah, when I'm just laying in bed like that, I have those moments where my brain works but only for a short time then it goes back to jello, so that I don't feel like a total useless drain on the world, (you know how it is when you just think the sick will never end) I play a game, trying to catch those working moments. And then try to use the brain power to solve a puzzle. And it keeps me out of depression.

4-Tania, you know I never really looked at that but it's interesting and now you've got me thinking about it.

4- Sam (waving) hey Sam

4-GlenP (waving) Hugs and warm puppy licks.

4-VilliageLife, Man that sucks about the anxiety and stress. Have you had a chance to try any stress reduction stuff??? I recommend Mindfullness based Stress reduction. You can get it up online. Or do concentration practice where you look at a candle or a soothing picture something like that maybe.

4- Ronnie, you my hero cause 3 and 5 are damn hard work. (big grins)

Hugs and warm puppy licks to everybody and hang in there. It will all come out in the wash we just have to be patient for at least another year. (sigh)

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