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De Meirlier Results - Part II

So, you should be aware, if you've simply clicked at the bottom of the prior entry, that fourteen weeks passed between this time and that. Like individual epochs. Like the movement of the icebergs, ladies and gentlemen. Like the years between George R.R. Martin novels.

From my experience with other patients of De Meirlier, we had very different expectations. I've never waited for more than a week or so for bloodwork before, and while I've had to wait awhile to see specialists before (an autonomic specialist, or a endocrinologist, for example) once you're at the doc's office, it's all over but the screaming. You get your blood drawn, results back in a week or so.

Apparently, that is not the way it works everywhere! While I waited for my results (impatiently, nervously, and, it may be said, quite vocally sorrowfully at times), I heard many times that it was quite normal to wait this long, not to worry, it will all come in time, and so on. Before we even get to the results, a few observations about DeMeirlier's process:

  • It takes ages.
  • He is very thorough.
  • He is a pragmatist who will use mainstream, experimental, and alternative medicine without turning his nose up at any method that has promise. Expect lifestyle advice too.
  • You are meant to intuit, through the use of your psychic powers, how things work. To put it more bluntly, find an old patient of DeMeirlier's and ask:
    • How you're to pay for your bloodwork
    • How long this typically takes
    • When he'll be in the U.S. next
    • When he'll be in Brussels next
    • Who to contact about what
    • How much an appointment costs
    • How much labwork tends to cost
    • How long to plan to stay in the area
    • How to contact their offices
...and so on and so forth, because DeMeirlier's office is too swamped to answer these questions, themselves. DeMeirlier is literally one of the only physicians in the world to do what he does, and one of the only ones who seems to do it without any fixed ideology. That is, he finds out whatever is wrong with you, often doesn't bother giving that an 'official name' and just hacks away at whichever problem stands tallest until it's been brought back down to size. Then, he hacks at the next problem down the list. It appears that he keeps on doing this until you reach some level of activity that you find acceptable, and though I haven't heard 'miracle cure' stories coming out of his offices, I hear many people talk about going off of medications and experiencing a greater activity level without damage after working with him.

For people with an illness that is not very well understood even by experts in the field, this is pretty much the ideal methodology, so far as I am concerned. And so far as many are concerned.

Which means he and his people are run off their feet trying to see everyone who wants to see them. Do they have enough funding to do this? No, absolutely they do not, but they keep trying. They need to hire someone to just write grants for them. (Hint, hint!) Probably a better use of their meagre funds than hiring someone else full-time.

So, enough of the song and dance! Here's a bit of a recap of what it was that I was going to be tested for. I've highlighted the stuff that turned up something interesting, and will discuss each individually below.

He opted to test my thyroid hormones anyway, along with some other vaguely hormonal stuff:

  • TSH
  • Free T3 (Vrij T3)
  • thyroid antibodies (anti-thyreoblobuline)
  • free testosterone
  • Vitamin D2 & 3
  • IgG only - 96 General Foods Sensitivity Test
  • Proinflammatory cytokines (IL1B, IL-6, 8, and 10, IL12p70, TNF, TGF-B1, MIP-1B, MCP1)
  • Perforin expression (NKC activity)
  • Elastase expression (neutrophil activation)
  • CD57 absolute count
  • IMPH (Immunophenotyping: CD4, CD8, and CD56 determination)
  • SCD14 (Soluble)
  • C3A serum level
  • C4A serum level
  • Prostaglandin E2 serum level
  • VEGF serum level
  • D-lactate serum level
  • nagalase activity (alpha-N-acetylgalactosaminidase)
...this apparently tests for the rare autosomal disorder Schindler disease. There is little to no chance I have this, of course, but what the hey. Maybe because of my tiny burst blood vessels I wasn't even aware I had? This seems ridiculous.

Now, from the wee beasties division:

  • Aspergillus niger IgG (Black Mold)
  • Mycoplasma spp. & Mycoplasma pneuomoniae (causes atypical pneumonia - not sure why this is here)
  • Anaplasma phagocytophilum (A tick-borne bacterium that causes human granulocytic granoplasmosis)
  • Borrelia burgdorferi sl (Lyme)
  • Bartonella spp. ('cat scratch fever')
  • Midichloria mitochondriii (Yes, it is named after Star Wars's midichlorians. And it lives in and eats mitchondria. Seriously, officially the scariest microorganism ever.)
  • Babesia (a malaria-like parasite)
  • Yersinia (can cause 'pseudo-appendicitis'... oooh.)
  • Chlamydias
  • Parovirus B19 (Which causes fifth disease, which sounds nothing like what I have, but he was thinking about the ruddiness of my cheeks, I suppose. Or my blush. Whichever. :rolleyes:)
  • Tularemia (a lovely suppurating illness caused usually by contact with bunnies.)
Okay, so have you noticed that the ones I was most skeptical even mattered are all the ones that were off?

Because I noticed that. :oops:

Okay, ladies and gentlemen, from the top:

Low free testosterone:

Low free testosterone can mean a few different things.

  • Your SHBG is high. Sex-hormone binding globulins 'capture' the sex hormones (testosterone, estrogen) so that they are not floating free in the bloodstream.
  • Your testosterone overall is low. This is not the case for me. I have a healthy amount of testosterone, on the higher end of normal for the ladies.
So far as my current level of understanding goes, this ties in with fatigue and listlessness, but is not associated with depressive disorders or anxiety. Most of the time, high SHBG and low free testosterone in women is associated with menopause. (Nice.) The helpful people on mainstream websites suggest testosterone creams and such.

Uh, no thanks.

My cholesterol levels are a bit low, and this means that all my hormone levels are a bit low. However, my free testosterone is low BEYOND low (1/20th lowest normal value), implying there's some other factor at work, there. Why is SHBG sequestering testosterone? The world may never know, beyond "this is associated with fatigue".

Food Sensitivities:

The results here are interesting, and probably pertinent to many people besides me.

You may have read on my 'what I do for M.E.' post that I've been gluten-free, dairy-free, and artificial-sweetener-free for some time, now. The artificial sweetener went first; then, the wheat; then, dairy.

While I was at Mayo, I had been told that regarding food sensitivities, if you really wanted to know whether you were allergic, you should consume some of those foods before the test. I couldn't quite make myself eat wheat or dairy before the test, so I expected that wheat and dairy would have lower allergic values than they ought to.

IgG allergens are classed from 0 --> 6 in this report. Four or higher is considered a 'high' level reaction.

Okay, knowing all that, here we go:

Type IV Reaction Class:
Dairy (including yogurt, casein, cottage cheese, and milk - some were high Type IIIs, such as cheddar cheese and mozzarella, and whey was a mid-level III).

Type III Reaction Class:
Chicken egg white
Baker's Yeast
Some dairy (see previous)

Type II:

Goat's milk
Sesame Seed
Brewer's yeast

The Type I aren't really worth bringing up. BUT - I'm not sensitive to wheat so much as I am to yeast. This is a pretty important distinction! I need to go the way of my People and eat grains that are unleavened. ;)

Note: the type II brewer's yeast coupled with decent liver function is probably why I am one of the few ME people I know who don't have issues with alcohol (so long as it's gluten-free). Type II allergens are really fine so long as you don't indulge too much or too often.

The fact that dairy was so high shocked me, especially since I'd been avoiding it. When I went off of it, I noted profound health changes, but I made a lot of other changes at the same time so, again, I didn't think much of it. I even thought my reaction was probably lactose intolerance. Guess not. I accidentally ate a chip with a cheese dusting the other day and my throat swelled up and got all scratchy - definitely a more pronounced reaction once you've been away from a food for awhile!

Having egg whites up there makes me sorrowful, but, well... I'll get over it. ;) On the bright side, duck eggs don't seem to have the same issue. And I can have goat's milk sometimes! This is likewise quite good news. :D I missed cheeses... and milk has Vit D and calcium and I would like to get those things!

High CD14

CD14 is a little bit of a confusing term, because depending on context, you could be discussing a protein, a gene, a SNP, or a type of monocyte. CD14 the protein has two types: one anchored to the cell, the other sCD14 (soluble), which is what is being measured in this assay. The protein is expressed by macrophages and, to a lesser extent, neutrophils, and it is its job to detect bacteria by their lipid polysaccharide coatings.

Okay, so this is fascinating. I found an article that says that high CD14 expression is linked to hyperglycemia (full text available). This ties in to my previous post regarding @ChrisArmstrong et al.'s study showing elevated glucose due to impaired glycolysis, and to Julie Newton's paper implying the same. (Yes, yes, I've read it now, but no post on it, yet.)

CD14 is also involved in the classification of monocytes.
There are CD14(+)CD16(-) (classical), CD14(+)CD16(+) (inflammatory), and CD14loCD16(+) (patrolling) monocytes that are all involved in attacking and killing the malaria plasmodium, for example. In other words, you might expect to see elevated CD14 values in an infection that would involve monocytes. CD14(+) monocytes can differentiate into dendritic (nerve) cells, which is equally weird and awesome. There's also some evidence that elevated CD14 might be associated with autoimmunity.

Mine wasn't super-high, just a bit above range.

Wow, I found a LOT out about the complement proteins, C3 and C4... but that's



Hey JaimeS,

Just though I would point out a couple of things: 1.) the nagalase test is to see whether to treat with GcMAF. There is a video where KDM explains this in detail, if you are interested; 2.) the soluble CD14 is an indirect way to test how much LPS you have in your bloodstream, which is an indirect way to test whether you have leaky gut or not.
Jaime - I'm just curious - Do you go to Reno to see this doctor and do they do these blood tests at his clinic? Is the cost for them included in your treatment? I don't go to him but I live in the area. There's a lab in Reno called Cash Clinical that doesn't take insurance and give DEEP discounts. You can self order here - I've ordered some pretty exotic tests through them - they send the more complicated ones out to Quest and the results are always in within a week. It could save money for those who are self pay if the doctor will allow it.
Wow, 2Cor - that sounds pretty amazing! No, KDM does not include the lab fees in the consultation fee. It's separate. He does seem pretty particular about where the tests go, but he's also pretty sensitive to / understanding of money issues, so if you explained that was why I think he'd be okay with it. :)
Great post, Jaime! Lots of food for thought there (no pun intended :D).

Just a couple weeks ago I read some stuff about nagalase that made the test more broadly applicable to some people other than just that narrow cohort, but I'm danged if I can remember anything about it except "nagalase". I only remmeber it because it made me want to get it tested. :lol: I'll look and see if I can find the info again...you might find it interesting.

Edited...as someone pointed out below, nagalase test is for GcMAF. Now I remember! ;)

Anyway, sounds like fun and that DeMerlier is fascinating to work with. Keep us posted on new developments!

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