I've collated a list of the most significant, published and unpublished, international positive XMRV studies that I know about, including the European and Japanese research studies ... along with a very brief summary of each of them.
I've included the links to the published papers, or to the unpublished abstracts, or to other sources the information if I haven't seen the actual papers.
If anyone knows of any more sources of info on any of these, or has links to the actual papers, then please could you let me know so I can add the info? Thank you.
There are other positive XMRV studies as well, but I have only included what I think are the most significant positive studies. (The studies I've included are testing people for XMRV, while the other studies are researching the nature of XMRV itself.)
Suggestions to include other studies will be gratefully received.
Initial discovery of XMRV in prostate cancer patients
XMRV was first discovered in 2006 in prostate cancer patients. Here is the published research paper...
"Identification of a novel Gammaretrovirus in prostate tumors of patients homozygous for R462Q RNASEL variant." 31st March 2006. by Urisman A, Molinaro RJ, Fischer N, Plummer SJ, Casey G, Klein EA, Malathi K, Magi-Galluzzi C, Tubbs RR, Ganem D, Silverman RH, DeRisi JL.
http://www.ncbi.nlm.nih.gov/pubmed/16609730?dopt=Abstract&holding=f1000,f1000m,isrctn
XMRV first discovered in ME/CFS patients
Judy Mikovits' paper was published in Science in Oct 2009.
XMRV detected in 67% of ME patients and 3.7% of healthy controls.
http://www.sciencemag.org/cgi/content/abstract/1179052
FDA/NIH study published in August 2010
Alter and Lo's FDA/NIH paper published in PNAS.
MLV-related viral sequences detected in 86.5% of ME/CFS patients and 6.8% of healthy controls.
http://www.pnas.org/content/early/2010/08/16/1006901107.full.pdf+html
The WPI's unpublished UK study:
Not yet published, but reported to be about 80% positive for XMRV in UK ME patients, and 6-8% positive in the UK blood supply.
See info from the CFIDS Association of America's website, here:
http://www.cfids.org/xmrv/wrkshp-data-comparison.pdf
http://www.forums.aboutmecfs.org/sh...CFS-Conference-Update-on-XMRV-by-Dr.-Mikovits
The WPI's unpublished study on families
Looking for XMRV in families and testing: adults with ME, FM, Lymme disease; Parents of children with neuroimmune disease; children with ASD; children with Niemann-Pick; and healthy children with sibling who have neuroimmune disease. Positive results obtained.
"Detection of infectious XMRV in the peripheral blood of children"
http://www.cfids.org/xmrv/wrkshp-data-comparison.pdf
http://www.forums.aboutmecfs.org/sh...CFS-Conference-Update-on-XMRV-by-Dr.-Mikovits
Dr Cheney and Dr Bell - unpublished studies
Separate unpublished studies in the USA, using patients from Dr Cheney's and Dr Bell's clinics, have confirmed high rates of XMRV infection in ME patients.
Dr Cheney:
74.5% of consecutive ME patients, who went to the Cheney Clinic, tested positive for XMRV.
http://www.cfids.org/xmrv/wrkshp-data-comparison.pdf
Dr Bell:
80% of 10 patients currently meeting Fukuda criteria tested positive for MLV-related sequences and 1% of healthy controls.
http://www.cfids.org/xmrv/wrkshp-data-comparison.pdf
http://www.cfids.org/xmrv/wrkshp-report.pdf
Japan (publication status unknown to me)
XMRV found in 1.7% of random healthy blood donor samples from the blood supply in Japan, testing for antibodies only. (This was a study of blood bank samples and prostate cancer patients, not ME patients.)
http://www.diagnosesupport.com/heal...ted-virus-in&catid=132:xmrv-research&Itemid=8
Germany (publication status unknown to me)
XMRV found in respiratory secretions in 3.2% of healthy control samples (study not carried out on ME patients).
Respiratory samples taken from patients with respiratory tract infection and healthy persons.
http://www.cdc.gov/EID/content/16/6/1000.htm
http://www.cdc.gov/EID/content/16/6/1000-T.htm
Norway (publication status unknown to me)
62% of patients tested positive for XMRV at the Lillestrom Health Clinic, using the VIPdx lab.
http://www.prohealth.com/library/showarticle.cfm?libid=15684
The Lillestrom Health Clinic tested 80 patients and 50 were tested positive by either culture or serology test a total of 62%. The tests were done in cooperation with VIPdx labs in the USA.
More information about these results will be given on the 28th of November 2010 in Oslo at the XMRV/MLV seminar with Dr. Judy Mikovits... See this link for more details of the November Oslo XMRV seminar:
http://esme-eu.com/home/xmrv-mlv-se...f-november-2010-oslo-norway-article423-6.html
In November 2010, the Lillestrom Health Clinic will launch a large international research project on Human Gammaretrovirus and ME.
Belgium (publication status unknown to me)
Study led by Professor De Meirleir.
Researchers at the Vrije Universiteit Brussel (VUB) and the Belgian company biotech RED Laboratories "are able to identify a new retrovirus in patients with chronic fatigue syndrome."
http://translate.google.co.il/trans...la-fatigue-chronique&sl=fr&tl=en&hl=&ie=UTF-8
http://www.forums.aboutmecfs.org/attachment.php?attachmentid=3848&d=1284150125
http://www.forums.aboutmecfs.org/showthread.php?7124-Meirleir-confirms-XMRV-findings-in-Europe
http://www.nieuws.be/nieuws/VUB-ond...chronisch_vermoeidheidssyndroom_6a743703.aspx
http://regist2.virology-education.com/abstractbook/2010_8.pdf
Spain (publication status unknown to me)
Pilot study by J Blanco et al:
http://regist2.virology-education.com/abstractbook/2010_8.pdf
http://www.forums.aboutmecfs.org/sh...-Spanish-XMRV-studies&highlight=spanish+study
Spain (progress of study unknown to me)
Hospital Vall d'Hebron in Barcelona:
http://www.abc.es/agencias/noticia.asp?noticia=574407
http://www.prohealth.com/library/showarticle.cfm?libid=15703
[It's uncertain that the facts have been reported correctly in this case - see discussion]
_____________________________________________________________________________________________
List of some of the ongoing research:
Harvey Alter (discovered the HEP C virus), working for the FDA investigating MLV-related viruses in ME/CFS patients. He is looking for antibodies, and will be isolating the virus, and sequencing the genome of the PMRV's which he found.
W. Ian Lipkin (internationally recognized for his work with West Nile virus and SARS) working for US government health agencies to investigate XMRV in ME patients.
http://blogs.wsj.com/health/2010/09...atest-xmrv-study/?KEYWORDS=amy+dockser+marcus
Frank and Sandra Ruscetti, working at the NCI (National Cancer Institute) carrying out research into XMRV and its effect on the immune system.
http://ccr.cancer.gov/staff/staff.asp?staffid=270
Dr Singh, carrying out some complex studies on XMRV.
http://www.forums.aboutmecfs.org/entry.php?585-Report-From-the-OFFER-2010-Conference
Judy Mikovits looking at a link between immune abnormalities and XMRV, XMRV in autism and atypical MS. Working on a UK study reportedly showing XMRV in about 80% of ME patients.
http://www.cfids.org/xmrv/wrkshp-data-comparison.pdf
http://www.forums.aboutmecfs.org/sh...CFS-Conference-Update-on-XMRV-by-Dr.-Mikovits
The US Blood Working Group is working towards standardising the methodology for detecting XMRV, and then they will do larger scale studies looking for XMRV in the population.
http://www.cfids.org/cfidslink/2009/120203.asp
http://aboutmecfs.org/Rsrch/XMRVStudies.aspx
http://blogs.wsj.com/health/2010/07...e-to-hear-about-xmrv-working-groups-research/
More info about upcoming XMRV studies:
http://www.forums.aboutmecfs.org/entry.php?595-What-s-Next-for-XMRV
http://aboutmecfs.org/Rsrch/XMRVStudies.aspx
Info about published, unpublished, proposed and ongoing research studies
Details (on Phoenix Rising website and forum) of proposed, upcoming, incomplete and unpublished research studies:
http://www.forums.aboutmecfs.org/entry.php?595-What-s-Next-for-XMRV
http://aboutmecfs.org/Rsrch/XMRVStudies.aspx
Details of all the published XMRV studies to date, including the two published positive USA studies, and all the negative published studies (A PDF chart, on the CFIDS Association of America's website):
http://www.cfids.org/xmrv/data-comparison-082410.pdf
Details of unpublished XMRV studies presented at the 1st International Conference on XMRV (A PDF chart, on the CFIDS Association of America's website):
http://www.cfids.org/xmrv/wrkshp-data-comparison.pdf
Abstract Book - 1st International Conference on XMRV
Collated research papers presented at the 1st International Conference on XMRV (A PDF document):
http://regist2.virology-education.com/abstractbook/2010_8.pdf
Recent articles regarding the state of play for XMRV research:
World Class Virus Hunter To Head Up the Latest XMRV Study.
http://blogs.wsj.com/health/2010/09...atest-xmrv-study/?KEYWORDS=amy+dockser+marcus
XMRV On Everyones Mind at a Chronic Fatigue Syndrome Meeting.
http://blogs.wsj.com/health/2010/10...syndrome-meeting/?KEYWORDS=amy+dockser+marcus
Recent news and progress:
http://www.forums.aboutmecfs.org/co...-in-the-balance-A-Tale-of-Two-Conferences-CFS
Ongoing and proposed XMRV research:
http://www.forums.aboutmecfs.org/entry.php?595-What-s-Next-for-XMRV
http://aboutmecfs.org/Rsrch/XMRVStudies.aspx
1st International Conference on XMRV
There is a selection of abstracts of XMRV studies presented the 1st International Conference on XMRV here:
"Abstract Book" - Collated research papers presented at the 1st International Conference on XMRV (A PDF document):
http://regist2.virology-education.com/abstractbook/2010_8.pdf
Details of unpublished XMRV studies presented at the 1st International Conference on XMRV (A PDF chart, on the CFIDS Association of America's website):
http://www.cfids.org/xmrv/wrkshp-data-comparison.pdf
I've included the links to the published papers, or to the unpublished abstracts, or to other sources the information if I haven't seen the actual papers.
If anyone knows of any more sources of info on any of these, or has links to the actual papers, then please could you let me know so I can add the info? Thank you.
There are other positive XMRV studies as well, but I have only included what I think are the most significant positive studies. (The studies I've included are testing people for XMRV, while the other studies are researching the nature of XMRV itself.)
Suggestions to include other studies will be gratefully received.
Initial discovery of XMRV in prostate cancer patients
XMRV was first discovered in 2006 in prostate cancer patients. Here is the published research paper...
"Identification of a novel Gammaretrovirus in prostate tumors of patients homozygous for R462Q RNASEL variant." 31st March 2006. by Urisman A, Molinaro RJ, Fischer N, Plummer SJ, Casey G, Klein EA, Malathi K, Magi-Galluzzi C, Tubbs RR, Ganem D, Silverman RH, DeRisi JL.
http://www.ncbi.nlm.nih.gov/pubmed/16609730?dopt=Abstract&holding=f1000,f1000m,isrctn
XMRV first discovered in ME/CFS patients
Judy Mikovits' paper was published in Science in Oct 2009.
XMRV detected in 67% of ME patients and 3.7% of healthy controls.
http://www.sciencemag.org/cgi/content/abstract/1179052
FDA/NIH study published in August 2010
Alter and Lo's FDA/NIH paper published in PNAS.
MLV-related viral sequences detected in 86.5% of ME/CFS patients and 6.8% of healthy controls.
http://www.pnas.org/content/early/2010/08/16/1006901107.full.pdf+html
The WPI's unpublished UK study:
Not yet published, but reported to be about 80% positive for XMRV in UK ME patients, and 6-8% positive in the UK blood supply.
See info from the CFIDS Association of America's website, here:
http://www.cfids.org/xmrv/wrkshp-data-comparison.pdf
http://www.forums.aboutmecfs.org/sh...CFS-Conference-Update-on-XMRV-by-Dr.-Mikovits
The WPI's unpublished study on families
Looking for XMRV in families and testing: adults with ME, FM, Lymme disease; Parents of children with neuroimmune disease; children with ASD; children with Niemann-Pick; and healthy children with sibling who have neuroimmune disease. Positive results obtained.
"Detection of infectious XMRV in the peripheral blood of children"
http://www.cfids.org/xmrv/wrkshp-data-comparison.pdf
http://www.forums.aboutmecfs.org/sh...CFS-Conference-Update-on-XMRV-by-Dr.-Mikovits
Dr Cheney and Dr Bell - unpublished studies
Separate unpublished studies in the USA, using patients from Dr Cheney's and Dr Bell's clinics, have confirmed high rates of XMRV infection in ME patients.
Dr Cheney:
74.5% of consecutive ME patients, who went to the Cheney Clinic, tested positive for XMRV.
http://www.cfids.org/xmrv/wrkshp-data-comparison.pdf
Dr Bell:
80% of 10 patients currently meeting Fukuda criteria tested positive for MLV-related sequences and 1% of healthy controls.
http://www.cfids.org/xmrv/wrkshp-data-comparison.pdf
http://www.cfids.org/xmrv/wrkshp-report.pdf
Japan (publication status unknown to me)
XMRV found in 1.7% of random healthy blood donor samples from the blood supply in Japan, testing for antibodies only. (This was a study of blood bank samples and prostate cancer patients, not ME patients.)
http://www.diagnosesupport.com/heal...ted-virus-in&catid=132:xmrv-research&Itemid=8
Germany (publication status unknown to me)
XMRV found in respiratory secretions in 3.2% of healthy control samples (study not carried out on ME patients).
Respiratory samples taken from patients with respiratory tract infection and healthy persons.
http://www.cdc.gov/EID/content/16/6/1000.htm
http://www.cdc.gov/EID/content/16/6/1000-T.htm
Norway (publication status unknown to me)
62% of patients tested positive for XMRV at the Lillestrom Health Clinic, using the VIPdx lab.
http://www.prohealth.com/library/showarticle.cfm?libid=15684
The Lillestrom Health Clinic tested 80 patients and 50 were tested positive by either culture or serology test a total of 62%. The tests were done in cooperation with VIPdx labs in the USA.
More information about these results will be given on the 28th of November 2010 in Oslo at the XMRV/MLV seminar with Dr. Judy Mikovits... See this link for more details of the November Oslo XMRV seminar:
http://esme-eu.com/home/xmrv-mlv-se...f-november-2010-oslo-norway-article423-6.html
In November 2010, the Lillestrom Health Clinic will launch a large international research project on Human Gammaretrovirus and ME.
Belgium (publication status unknown to me)
Study led by Professor De Meirleir.
Researchers at the Vrije Universiteit Brussel (VUB) and the Belgian company biotech RED Laboratories "are able to identify a new retrovirus in patients with chronic fatigue syndrome."
http://translate.google.co.il/trans...la-fatigue-chronique&sl=fr&tl=en&hl=&ie=UTF-8
http://www.forums.aboutmecfs.org/attachment.php?attachmentid=3848&d=1284150125
http://www.forums.aboutmecfs.org/showthread.php?7124-Meirleir-confirms-XMRV-findings-in-Europe
http://www.nieuws.be/nieuws/VUB-ond...chronisch_vermoeidheidssyndroom_6a743703.aspx
http://regist2.virology-education.com/abstractbook/2010_8.pdf
Rivotril;115299 said:
Spain (publication status unknown to me)
Pilot study by J Blanco et al:
http://regist2.virology-education.com/abstractbook/2010_8.pdf
http://www.forums.aboutmecfs.org/sh...-Spanish-XMRV-studies&highlight=spanish+study
Spain (progress of study unknown to me)
Hospital Vall d'Hebron in Barcelona:
http://www.abc.es/agencias/noticia.asp?noticia=574407
http://www.prohealth.com/library/showarticle.cfm?libid=15703
[It's uncertain that the facts have been reported correctly in this case - see discussion]
_____________________________________________________________________________________________
List of some of the ongoing research:
Harvey Alter (discovered the HEP C virus), working for the FDA investigating MLV-related viruses in ME/CFS patients. He is looking for antibodies, and will be isolating the virus, and sequencing the genome of the PMRV's which he found.
W. Ian Lipkin (internationally recognized for his work with West Nile virus and SARS) working for US government health agencies to investigate XMRV in ME patients.
http://blogs.wsj.com/health/2010/09...atest-xmrv-study/?KEYWORDS=amy+dockser+marcus
Frank and Sandra Ruscetti, working at the NCI (National Cancer Institute) carrying out research into XMRV and its effect on the immune system.
http://ccr.cancer.gov/staff/staff.asp?staffid=270
Dr Singh, carrying out some complex studies on XMRV.
http://www.forums.aboutmecfs.org/entry.php?585-Report-From-the-OFFER-2010-Conference
Judy Mikovits looking at a link between immune abnormalities and XMRV, XMRV in autism and atypical MS. Working on a UK study reportedly showing XMRV in about 80% of ME patients.
http://www.cfids.org/xmrv/wrkshp-data-comparison.pdf
http://www.forums.aboutmecfs.org/sh...CFS-Conference-Update-on-XMRV-by-Dr.-Mikovits
The US Blood Working Group is working towards standardising the methodology for detecting XMRV, and then they will do larger scale studies looking for XMRV in the population.
http://www.cfids.org/cfidslink/2009/120203.asp
http://aboutmecfs.org/Rsrch/XMRVStudies.aspx
http://blogs.wsj.com/health/2010/07...e-to-hear-about-xmrv-working-groups-research/
More info about upcoming XMRV studies:
http://www.forums.aboutmecfs.org/entry.php?595-What-s-Next-for-XMRV
http://aboutmecfs.org/Rsrch/XMRVStudies.aspx
Info about published, unpublished, proposed and ongoing research studies
Details (on Phoenix Rising website and forum) of proposed, upcoming, incomplete and unpublished research studies:
http://www.forums.aboutmecfs.org/entry.php?595-What-s-Next-for-XMRV
http://aboutmecfs.org/Rsrch/XMRVStudies.aspx
Details of all the published XMRV studies to date, including the two published positive USA studies, and all the negative published studies (A PDF chart, on the CFIDS Association of America's website):
http://www.cfids.org/xmrv/data-comparison-082410.pdf
Details of unpublished XMRV studies presented at the 1st International Conference on XMRV (A PDF chart, on the CFIDS Association of America's website):
http://www.cfids.org/xmrv/wrkshp-data-comparison.pdf
Abstract Book - 1st International Conference on XMRV
Collated research papers presented at the 1st International Conference on XMRV (A PDF document):
http://regist2.virology-education.com/abstractbook/2010_8.pdf
Recent articles regarding the state of play for XMRV research:
World Class Virus Hunter To Head Up the Latest XMRV Study.
http://blogs.wsj.com/health/2010/09...atest-xmrv-study/?KEYWORDS=amy+dockser+marcus
XMRV On Everyones Mind at a Chronic Fatigue Syndrome Meeting.
http://blogs.wsj.com/health/2010/10...syndrome-meeting/?KEYWORDS=amy+dockser+marcus
Recent news and progress:
http://www.forums.aboutmecfs.org/co...-in-the-balance-A-Tale-of-Two-Conferences-CFS
Ongoing and proposed XMRV research:
http://www.forums.aboutmecfs.org/entry.php?595-What-s-Next-for-XMRV
http://aboutmecfs.org/Rsrch/XMRVStudies.aspx
1st International Conference on XMRV
There is a selection of abstracts of XMRV studies presented the 1st International Conference on XMRV here:
"Abstract Book" - Collated research papers presented at the 1st International Conference on XMRV (A PDF document):
http://regist2.virology-education.com/abstractbook/2010_8.pdf
Details of unpublished XMRV studies presented at the 1st International Conference on XMRV (A PDF chart, on the CFIDS Association of America's website):
http://www.cfids.org/xmrv/wrkshp-data-comparison.pdf