ramakentesh

An alternative hypothesis: Chronic activation of the innate immune system through upregulation of TNF alpha and NF-kappa expression results in sodium channelophy and an upregulation of the sensitivity of the sympathetic nervous system through increased voltage-gated sodium channel stimulation...

My hypothesis: CFS/ME is a manifestation of increased cerebral lactate, impaired glucose metabolism and reduced cerebral antioxidant activity as a result of postural reductions in blood flow to the brain. These reductions may manifest as POTS or NMH but may also manifest as abnormal cerebral...