Phoenix Rising Articles

Nitric oxide and its possible implication in ME/CFS (Part 1 of 2)

  • 17,809
  • 34
Legendrew submitted a new blog post:

Nitric oxide and its possible implication in ME/CFS (Part 1 of 2)

Andrew Gladman explores the current and historic hypotheses relating to nitric oxide problems in ME/CFS. Part 1 of a 2-part series puts nitric oxide under the microscope and explores what it is, what it does and why it is so frequently discussed in the world of ME/CFS. Part 1 focuses on what nitric oxide is, how its produced and what exactly it does ...

Over the years there have quite a number of proposed disease mechanisms relating to nitric oxide (NO) problems of patients suffering with ME/CFS. Studies have however, over the years, proven somewhat inconclusive in the past.

Dr. Pall is...

New Exercise Study Brings Both Illumination and Questions

  • 27,855
  • 61
Simon submitted a new blog post:

New Exercise Study Brings Both Illumination and Questions

Simon McGrath looks at new objective evidence of abnormal response to exercise in ME/CFS patients, and the questions that researchers are still trying to answer ...


Exercise testing at Dr. Keller's lab

Given the doubt, scepticism and even denial of benefits that often confronts ME/CFS patients, it’s not surprising that many patients crave clear-cut, objective evidence of physiological problems in the illness. Preferably something that will explain at least some of the perplexing symptoms. Something that will say: “this is real”.

And finally it seems researchers might be closing in on this.

Two-day maximal exercise tests promise to provide objective evidence for the most striking and unusual feature of the...

August 8th - What is the one thing about suffering with severe ME that the world needs to know?

  • 13,599
  • 14
Legendrew submitted a new blog post:

August 8th - What is the one thing about suffering with severe ME that the world needs to know?

Andrew Gladman brings our coverage of the Understanding & Remembrance Day for Severe ME, airing the voice of patients ...

Long, lazy August afternoons. The sun is shining, the birds are singing, the garden growing, and the children are free from school. For many this time of year means holidays, family get-togethers, and a period of general relaxation.

However, for sufferers of severe ME, this time of year is rapidly becoming more and more a time for a united effort to get severe ME onto the radar of the general population.

The time has once again come for us to report upon the...

9th Invest in ME International ME Conference, 2014 - Part 2: Pathogens and the Gut

  • 16,855
  • 20
Mark submitted a new blog post:

9th Invest in ME International ME Conference, 2014 - Part 2: Pathogens and the Gut

Mark Berry continues his series of articles on the 9th Invest in ME International ME Conference in London, with the emphasis shifting from autoimmunity to pathogens and the gut ...

This is the second in a series of articles reporting on the 9th Invest in ME International ME Conference (IIMEC9), held as usual in the Lecture Theatre at 1 Birdcage Walk in Westminster on May 30th, 2014.
You can view the full conference programme (with biographies of the speakers) here, and the Conference Journal is available...

ME/CFS and the Magic of the Canine Factor

  • 14,950
  • 58
Jody submitted a new blog post:

ME/CFS and the Magic of the Canine Factor

Jody Smith has been taken by surprise by the value of having a dog when dealing with ME/CFS ...

There's been plenty of research indicating that having pets is good for your health. I never really noticed any particular benefits to having cats, though that may have had more to do with my cats. They've been fairly indifferent to my presence and we've shared a live-and-let-live type of relationship over the years.

Then I got a dog.


Cleo

I didn't even want this dog in the beginning, to be honest. My son Duncan had adopted Cleo, a German Shepherd-Lab mix that had ended up at the Humane Society after an injury that...

Hyperparathyroidism: An Often Overlooked Differential Diagnosis to ME/CFS

  • 20,351
  • 49
Legendrew submitted a new blog post:

Hyperparathyroidism: An Often Overlooked Differential Diagnosis to ME/CFS

Andrew Gladman puts hyperparathyroidism under the microscope, exploring what the disease is, how it can mimic ME/CFS in presentation and how it is treated.

Chronic fatigue syndrome or ME/CFS is, whether we like it or not, by current definition a diagnosis of exclusion. The biggest diagnostic task is therefore differentiating it from the plethora of other disorders that also have a fatigue component.

ME/CFS may be distinguished from other causes of fatigue on the basis of certain presenting symptoms such as cognitive dysfunction, which is not present in almost all other fatigue-producing disorders. Once a specific cause of fatigue has been diagnosed, CFS is then excluded, by definition.

The problem that arises, however, is that almost any chronic illness that produces extensive...

ME/CFS and Beating the Clock

  • 5,859
  • 6
Jody submitted a new blog post:

ME/CFS and Beating the Clock

For Jody Smith, the ticking of a clock was enough at one time to chase her back to her bed. But with the passage of time, she has been able to reclaim her living room ...

I have two clocks in my living room. One clock is on the wall across from where I usually sit at my computer. The other is on the wall to my left. I guess this might be an unusual arrangement, not to be found in most homes, but it has been practical for me.

I have had long intense bouts of what I have called tendinitis over the years, affecting my neck, shoulders, arms, hands, legs and feet. My guess is that this is part of my particular brand of ME/CFS, but who...

9th Invest in ME International ME Conference, 2014 - Part 1: Autoimmunity and ME

  • 8,129
  • 7
Mark submitted a new blog post:

9th Invest in ME International ME Conference, 2014 - Part 1: Autoimmunity and ME

Mark Berry begins a series of articles on the 9th Invest in ME International ME Conference in London, with a look at three presentations on autoimmunity



This is the first in a series of articles reporting on the 9th Invest in ME International ME Conference (IIMEC9), held as usual in the Lecture Theatre at 1 Birdcage Walk in Westminster on May 30th, 2014.

You can view the full conference programme (with biographies of the speakers) here, and the Conference Journal is available as a PDF document...

Never Ask Us if We're Hungry -- The Answer's Always No

  • 16,299
  • 48
Jody submitted a new blog post:

Never Ask Us if We're Hungry -- The Answer's Always No

If you're ever at Jody Smith's house, don't bother asking anybody if they are hungry ...



One of the most ridiculous questions you can ask in my house is "Are you hungry?"

There are three of us here and for many years, none of us ever got hungry. When our brains would turn to mush, when our faces would go numb, and we would start the invisible vibration which is the signature dance of ME/CFS, we knew we needed to eat.

Or rather, we knew we should have eaten something about twenty minutes ago and saved ourselves this distress.

For me, this realization hit after I started eating low carb. I was making a point of eating about every four...

Part 2: Brain Cells Making us Sick? Messed up microglia could be driving symptoms

  • 11,145
  • 35
Simon submitted a new blog post:

Part 2: Brain Cells Making us Sick? Messed up microglia could be driving symptoms

Simon McGrath looks at theories that microglia, the brain's immune cells, might be overactive and driving the symptoms of ME/CFS and fibromyalgia.

In Part 1, he described how the body reacts to infection or wounding with a “sickness response” that partly resembles ME/CFS, and how the microglia are the last step in the physiological mechanisms that lead to sickness response.
Could microglia be behind the symptoms of ME/CFS? Artist's image of a microglia. © 2012 Hagop...

Brain Cells Making us Sick? The microglia connection in ME/CFS & Fibromyalgia

  • 12,487
  • 32

(click title to view blog properly)
Simon McGrath looks at theories that microglia, the brain's immune cells, could trigger and perpetuate the symptoms of ME/CFS and fibromyalgia.

'Sickness Behaviour': the immune system releases cytokines in response to infection, which activates microglia in the brain and creates symptoms including fatigue, pain and cognitive problems.

Your dog can’t tell you when she's feeling sick, but even so, you know. She moves slowly, she doesn’t eat, she sleeps a lot, she curls up in a corner by herself. “Sickness behavior" is shared by all mammals, and in humans...

Lessons from ME/CFS: Finding Meaning in the Suffering

  • 6,053
  • 17
Legendrew submitted a new blog post:

Lessons from ME/CFS: Finding Meaning in the Suffering

Andrew Gladman muses upon what lessons he has taken from two years of ME/CFS.

If you're aware of my previous articles here at Phoenix Rising then it's pretty clear that I don't generally spend my time musing upon the philosophy of the disease. I find it better to spend my time reading research and trying my best to break it down to its core elements and write about it.



Every now and then, however, I like to dip my toes in and test the waters per say at the other end of the spectrum.

Recently I've been musing upon what my illness has taught me about myself and the greater world we live in. I'm not a believer in the notion...

ME/CFS: In Free Fall Through the Looking Glass

  • 11,263
  • 50
Phoenix Rising Team submitted a new blog post:

ME/CFS: In Free Fall Through the Looking Glass

Jody Smith continues to try to put into words the horror of the altered state that hobbles the brains of those with ME/CFS...

...

If you're not a fan of hallucinatory drugs you're gonna hate ME/CFS.

When I first became ill in March of 1992, the feeling of altered reality inside my head, the shaking which could not be seen in my arms and hands and which later spread to the rest of my body, the uncertainty with which I navigated, never quite sure I could physically accomplish a walk across the floor without falling or bumping into things ... these things were bizarre and alarming.

The inability to think clearly, to be able to comprehend what...

No Longer Naive in the Ways of The Beast

  • 11,132
  • 46
View the Post on the Blog

After having lived for years with ME/CFS, Jody Smith learned there's more to this beast of an illness than she realized, and that what might help one person may not help others ...


When I first got back online five years ago, I was naive in the ways of this beast we call ME/CFS. I guess I thought that whatever it was that I had was what you had ... what they had ... what that person laying on their face over there had ...

Turns out I couldn't have been more wrong.

I had been slowly recovering and I wanted so much to share what I learned with other people who were sick because then they would all get better too.

Yeah. Kind of naive.

I started supplying free articles on ME/CFS to...

The Fable known as The PACE Trial

  • 14
  • 0
View the Post on the Blog

Graham, Janelle and Bob, have once again excelled themselves with their latest take on the 'poisoned apple' that was the PACE Trial...

Once upon a time, long, long ago a king and queen ruled over a distant land. The queen was kind and….

Whoops, sorry there! I got confused for a moment. Wrong fantasy tale...

Several years ago a team of psychologists and psychiatrists published the first of their fables about the effectiveness of CBT (and graded exercise) in treating ME/CFS. It was known throughout the world as “The PACE Trial”.

A group of valiant, honest crusaders, mostly members of Phoenix Rising, struggled diligently and...

The Fable known as The PACE Trial

  • 8,269
  • 35
View the Post on the Blog

Graham, Janelle and Bob, have once again excelled themselves with their latest take on the 'poisoned apple' that was the PACE Trial...

Once upon a time, long, long ago a king and queen ruled over a distant land. The queen was kind and….

Whoops, sorry there! I got confused for a moment. Wrong fantasy tale...

Several years ago a team of psychologists and psychiatrists published the first of their fables about the effectiveness of CBT (and graded exercise) in treating ME/CFS. It was known throughout the world as “The PACE Trial”.

A group of valiant, honest crusaders, mostly members of Phoenix Rising, struggled...

First Direct Evidence of Neuroinflammation - 'Encephalitis' - in ME/CFS

  • 17
  • 0
View the Post on the Blog

Simon McGrath reports on the new study that indicates low-grade encephalitis in ME/CFS ...

A small study with just nine patients has captured the attention of patients and researchers alike after reporting direct evidence of inflammation in the brain of ME/CFS patients. The finding was one of the highlights picked out by Professor Anthony Komaroff in his IACFS/ME conference round up.

Neuroinflammation may be behind ME/CFS symptoms
Photo credit: Canstock...

First Direct Evidence of Neuroinflammation - 'Encephalitis' - in ME/CFS

  • 21
  • 0
View the Post on the Blog

Simon McGrath reports on the new study that indicates low-grade encephalitis in ME/CFS ...

A small study with just nine patients has captured the attention of patients and researchers alike after reporting direct evidence of inflammation in the brain of ME/CFS patients. The finding was one of the highlights picked out by Professor Anthony Komaroff in his IACFS/ME conference round up.

Neuroinflammation may be behind ME/CFS symptoms
Photo credit: Canstock...

First Direct Evidence of Neuroinflammation - 'Encephalitis' - in ME/CFS

  • 35,127
  • 134
View the Post on the Blog

Simon McGrath reports on the new study that indicates low-grade encephalitis in ME/CFS ...

A small study with just nine patients has captured the attention of patients and researchers alike after reporting direct evidence of inflammation in the brain of ME/CFS patients. The finding was one of the highlights picked out by Professor Anthony Komaroff in his IACFS/ME conference round up.


Neuroinflammation may be behind ME/CFS symptoms
Photo credit: Canstock...

The Mighty Egg: New Life Springs Forth Despite ME/CFS

  • 4,536
  • 18
View the Post on the Blog

Jody Smith finds that even with ME/CFS, new life as symbolized by the mighty egg, can still spring forth ...


The egg has been a symbol of new life since ancient times. Recently, this symbolism has struck home for me personally.

I've eaten a lot of eggs in my time. Particularly in my vegetarian years, I leaned heavily on eggs. Fried, boiled, on their own and in omelets ... And I confess in retrospect that I took them for granted. They were a mainstay that I perhaps didn't fully appreciate till I could no longer eat them.

In February of 2002 I was vaguely aware of a queasiness that...