Hi All,
I've been looking at some of the latest research around P11 (S100A10) protein and its mood effects.. It 's fascinating to me as a good candidate for a unified explanation of archetypal depression...
Brief overview of what we're talking about here: https://en.wikipedia.org/wiki/S100A10
-From my understanding the P11 protein binds to serotonin receptor proteins and effectively amplifies the neurotransmitter signals.
- Gamma Interferons (IFN-y ) and TNF-a increase P11 protein levels https://www.ncbi.nlm.nih.gov/pubmed/12645529
- NSAID's ibuprofen etc. block IFN-y and TNF-a, preventing up-regulation of P11 (explaining interaction with reduced SSRI effectiveness)
http://healthland.time.com/2011/04/25/how-advil-thwarts-the-effects-of-prozac/
- BDNF also increases expression of P11 protein, explaining Omega 3's, exercise effectiveness for lifting depression
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2929288/
-In major depression people have lower levels of P11 (prior to treatment with SSRi's MAOI's etc)
- SSRI's, MAOI's, and ECT all raise P11 levels eventually, generally coinciding with the symptoms lifting
- Ketamine up-regulates P11 protein, for a sustained duration, correlating with symptomatic relief
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4872431/
-Gene Therapy on the P11 S100A10 gene reverses depression in rodents.
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3026098/
-Nobel prize winner Dr. Paul Greengaurd has a very interesting patent posted around using P11 for the next generation treatments of depression http://www.google.com/patents/EP2659913A2?cl=en , and a study here
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3933996/
I'm interested in (cautiously & scientifically!) hopping on-board for mood & energy improvements...
Can anybody suggest supplementary or dietary methods one might go about increasing expression of P11 (S100A10).. elevating Gamma Interferons (IFN-y ) and TNF-alpha levels?...and also avoiding its down-regulation.
Interestingly I previously had great results from NAC (n-acetylcysteine) which does also raise IFN-y and P11 https://www.ncbi.nlm.nih.gov/pubmed/12165081 ,
I've been looking at some of the latest research around P11 (S100A10) protein and its mood effects.. It 's fascinating to me as a good candidate for a unified explanation of archetypal depression...
Brief overview of what we're talking about here: https://en.wikipedia.org/wiki/S100A10
-From my understanding the P11 protein binds to serotonin receptor proteins and effectively amplifies the neurotransmitter signals.
- Gamma Interferons (IFN-y ) and TNF-a increase P11 protein levels https://www.ncbi.nlm.nih.gov/pubmed/12645529
- NSAID's ibuprofen etc. block IFN-y and TNF-a, preventing up-regulation of P11 (explaining interaction with reduced SSRI effectiveness)
http://healthland.time.com/2011/04/25/how-advil-thwarts-the-effects-of-prozac/
- BDNF also increases expression of P11 protein, explaining Omega 3's, exercise effectiveness for lifting depression
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2929288/
-In major depression people have lower levels of P11 (prior to treatment with SSRi's MAOI's etc)
- SSRI's, MAOI's, and ECT all raise P11 levels eventually, generally coinciding with the symptoms lifting
- Ketamine up-regulates P11 protein, for a sustained duration, correlating with symptomatic relief
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4872431/
-Gene Therapy on the P11 S100A10 gene reverses depression in rodents.
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3026098/
-Nobel prize winner Dr. Paul Greengaurd has a very interesting patent posted around using P11 for the next generation treatments of depression http://www.google.com/patents/EP2659913A2?cl=en , and a study here
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3933996/
I'm interested in (cautiously & scientifically!) hopping on-board for mood & energy improvements...
Can anybody suggest supplementary or dietary methods one might go about increasing expression of P11 (S100A10).. elevating Gamma Interferons (IFN-y ) and TNF-alpha levels?...and also avoiding its down-regulation.
Interestingly I previously had great results from NAC (n-acetylcysteine) which does also raise IFN-y and P11 https://www.ncbi.nlm.nih.gov/pubmed/12165081 ,