studying fatigue in vitro: skeletal muscles in cardiac failure

[WillowJ]

Studying muscle function to advance treatment of heart failure
August 6th, 2014

One of the basic ideas to be tested is how and why the presence of metabolites act to slow the velocity of contraction in fatigued muscles.

A second aim is to understand how these same metabolites disrupt the regulation of muscle contraction, specifically why a separate set of muscle proteins, tropomyosin and troponin, become less sensitive to their molecular trigger calcium.

http://phys.org/wire-news/168790204...on-to-advance-treatment-of-heart-failure.html

 

[lansbergen]

They assume there is nohting wrong with the calcium system. I doubt that.