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[study] Jan 2023 Probiotic for pathogen-specific Staphylococcus aureus decolonisation

godlovesatrier

Senior Member
Messages
2,554
Location
United Kingdom
https://www.thelancet.com/journals/lanmic/article/PIIS2666-5247(22)00322-6/fulltext

"The trial was done between Jan 29 and June 30, 2021, with enrolment taking place from Jan 29 to April 6, 2021. 115 participants were colonised by S aureus, either in the intestine (n=84), nose (n=50), or both (n=19), and were randomly assigned to treatment (n=55) and placebo groups (n=60). Oral probiotic B subtilis resulted in significant reduction of S aureus in stool (96·8%; p<0·0001) and nose (65·4%; p=0·0002). There were no differences in adverse effects or significant microbiome changes between the intervention and placebo groups."

I've never seen bacilus show up on any of my 16s reports but I did see s aureus pop up once and then disappear in the next sample, could have been a lab error.

But thought those who had discussed S Aureus infection of the nasopharynx might find this useful info as this showed oral therapy helped.

In my case I took some a few days ago to re-try it and have just had quite bad fatigue nad brainfog whenever I eat any food, feel pretty good if I don't eat tho - hope that's a good sign! When I first took subtilis right at the start it made me have the best sleep I'd had in 8 years, sadly that only lasted about a week. It's a strong probiotic tho, the immune reaction I had when I took it was pretty full on and lasted 24 hours.