Lymphocyte subset testing

[heapsreal]

http://www.australianprescriber.com/magazine/33/3/84/7

Table 1
Characteristic clinical presentations of immunodeficiency
Type of immunodeficiency Clinical presentation
Humoral immunodeficiency
Hypogammaglobulinaemia Recurrent sinopulmonary infection:
- Streptococcus pneumoniae
- Haemophilus influenzae
- Neisseria species
Other bacterial infections such as gastrointestinal, central nervous system, joint
Evidence of end-organ damage such as bronchiectasis, conductive hearing loss
Cellular immunodeficiency
T cell dysfunction Infections with:
- intracellular bacteria (mycobacteria, salmonella)
- viruses (Epstein Barr, cytomegalovirus, varicella zoster,
herpes simplex)
- fungi (candida, aspergillus, cryptococcus, histoplasma,
pneumocystis)
- protozoa (toxoplasma, microsporidium, cryptosporidium)
Interleukin-12 interferon gamma axis deficiency Atypical mycobacterial and salmonella infections
Impaired response to Candida species Persistent mucocutaneous candidiasis
Autoimmune endocrinopathy

 

[heapsreal]

http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1809442/

Compared to patients with multiple sclerosis, patients with CFS had greater numbers of CD16+/CD3– NK cells. Further study will be required to determine whether these alterations in lymphocyte subsets are directly involved in the pathophysiology of these disorders, or are secondary effects of the causal agent(s).



Numbers of activated CD8+/CD38+ cells tended to be increased in patients with CFS compared to patients with MS, and numbers of CD8+/HLA-DR+ cells tended to be higher in patients with CFS than in healthy controls.