Hypoxia Increases Glutamate Secretion by Retinal Pigmented Epithelial Cells

[Violeta]

https://iovs.arvojournals.org/artic... large,the availability of intracellular iron.

Mary C. McGahan; Malgorzata Goralska; Lloyd Fleisher; Marilyn Lall; Steven Nagar; Philip Mzyk; Jill Harned
From 2011

Hypoxia induced a very large increase in the secretion of glutamate. The ability of iron chelation and inhibition of aconitase activity to decrease the hypoxia-induced increase in glutamate secretion indicate that hypoxia increases the availability of intracellular iron.

 

[Violeta]

Hypoxia Suppresses Glutamate Transport in Astrocytes​

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6672540/

"Glutamate uptake by astrocytes is fundamentally important in the regulation of CNS function. Disruption of uptake can lead to excitotoxicity and is implicated in various neurodegenerative processes as well as a consequence of hypoxic/ischemic events."

 

[Violeta]

Hypoxia and viral infectious diseases​

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8119216/

"Oxygen-sensing mechanisms allow cells to adapt and respond to changes in cellular oxygen tension, including hypoxic conditions. Hypoxia-inducible factor (HIF) is a central mediator in this fundamental adaptive response, and has critical functions in normal and disease physiology. Viruses have been shown to manipulate HIFs during their life cycle to facilitate replication and invasion."