gregh286
Senior Member
- Messages
- 976
- Location
- Londonderry, Northern Ireland.
hi guys,
interesting read from some years back.
Didnt see much discussion about that gene on here but seems very closely tied to our conditions and how it is capable to shut down mito function for protection.
https://www.hopkinsmedicine.org/Press_releases/2006/03_07_06.html
“The unexpected discovery is that this genetic switch actively shuts off the mitochondrion under low oxygen conditions, apparently to protect cells from mitochondrial toxic oxygen pollutants,” said...
A metabolic switch:
“Instead, HIF-1 acts as a genetic switch to actively shut down mitochondrial function and prevent the production of reactive oxygen species.
There are available inhibitors and activators for HIF-1
https://www.abcam.com/reagents/hif-inhibitors-and-activators
interesting read from some years back.
Didnt see much discussion about that gene on here but seems very closely tied to our conditions and how it is capable to shut down mito function for protection.
https://www.hopkinsmedicine.org/Press_releases/2006/03_07_06.html
“The unexpected discovery is that this genetic switch actively shuts off the mitochondrion under low oxygen conditions, apparently to protect cells from mitochondrial toxic oxygen pollutants,” said...
A metabolic switch:
“Instead, HIF-1 acts as a genetic switch to actively shut down mitochondrial function and prevent the production of reactive oxygen species.
There are available inhibitors and activators for HIF-1
https://www.abcam.com/reagents/hif-inhibitors-and-activators
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