Help understanding homozygous mutations in both COMT and BHMT?

[Gillby1]

Hi all,

Getting my 23andme results has opened up a whole new and fascinating world for me, but my brain is now frazzled from all of the new information and I don't even know where to start with supplements due to all the contra-indications! I've not been feeling well for some time, am knackered (although that may be due to having two young boys!) and i know my B12 and vitamin D are low. I hate to ask for help, as i know some of you spend all day answering similar questions, but does anyone have time to have a go at interpreting the results below?

Homozygous mutations

• COMT V158M
• COMT H62H
• BHMT-02
• BHMT-08

Heterozygous mutations

• VDR Bsm
• VDR Taq
• MTRR A66G
• CBS C699T
• CBS A360A
• MTHFR A1298C

I also seem to have rare genes rs60782127 and rs1156836. Where do i start with understanding these (as googling hasn't helped) or is that not always possible?

Thanks,

Gill

 

[ppodhajski]

COMT uses Magnesium as a cofactor and is also dependent on SAMe to break down catecholamines (dopamine, epinephrine, etc)
http://www.uniprot.org/uniprot/P21964

BHMT2 uses Zinc as a cofactor, which helps make more methionine which can help making more SAMe.
http://www.uniprot.org/uniprot/Q9H2M3

For me I would start investigating how magnesium and zinc makes me feel.

But to me will not solve everything. There are a lot more genes to look at. My first suggestion is that you get a report from http://promethease.org

Your D and B12 levels can be low for a lot of reasons. CYP2R1 SNPs can lower D levels. (I have those) It uses Iron as a cofactor.
http://www.uniprot.org/uniprot/Q6VVX0

Also, have you had a complete blood test done recently? Iron is something that will pop in my mind first with females. There are some genes you can check for your proclivity for low iron as well.

Low iron is linked to low D as I showed above.
http://www.nutritionatc.hawaii.edu/HO/2012/494.htm

 

[Gillby1]

Thanks for this. I will go via promethease and see what else turns up, and Magnesium and Zinc sound like a good place to start. Do you know which form of Magnesium might be best?

Iron levels are fine, as is serum folate (and as I don't supplement with folic acid I assume that these should be functional folate levels) and electrolytes.

Thanks again!

Gill