Galectin 3 - Modified Citrus Pectin

[LINE]

Galectin 3 is produced by the body (part of the immune response) likely due to a pathogenic invasion which could be viral, gut bugs etc. It is associated with inflammatory conditions, auto-immune, cancers, heart disease etc.

It is thought that modified citrus pectin can inhibit Galectin 3. I just started on the PectaSol which is supposed to be a superior version of modified citrus pectin.

Published paper on Gal 3

https://www.mdpi.com/1422-0067/19/2/379

Past Posts on PR on Galectin 3

https://forums.phoenixrising.me/threads/galectin-3-the-all-purpose-test-youve-never-heard-of.29557/

 

[LINE]

Update: I have achieved noticeable results, less pain, more flexibility, better mood. I also took enzymes which included a number of enzymes including nattokinase and serrapeptase. I also use a PEMF device which is said to help the body regenerate.

 

[datadragon]

Yes, Modified Citrus Pectin blocks Galectin-3 activity that drives fibrosis by reducing macrophage activity, proinflammatory cytokine expression, and apoptosis, as well as lowering inflammatory markers, thereby reducing tissue fibrosis. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5576403/ A role of Galectin-3 is the specific binding to NLRP3, and inflammasome activation (which is why I suggested that more as the target generally) https://pubmed.ncbi.nlm.nih.gov/32707678/

MCP also has the ability to reduce heavy metal toxicity. Here are 5 case reports as an example but generally something like acz nano may be easier for most if there is no kidney issue https://www.researchgate.net/public...avy_Metal_Chelation_and_Detoxification_-_Five and https://web.archive.org/web/20040905192740/http://annieappleseedproject.org/modcitpechea.html

and the original report by Dr Eliaz https://web.archive.org/web/2014072...content/sitebuilderfiles/pectasolc-report.pdf

Galectin-3 (Gal-3) regulates basic cellular functions such as cell–cell and cell–matrix interactions, growth, proliferation, differentiation, and inflammation. It is not surprising, therefore, that this protein is involved in the pathogenesis of many relevant human diseases, including cancer, fibrosis, chronic inflammation and scarring affecting many different tissues. The papers published in the literature have progressively increased in number during the last decades, testifying the great interest given to this protein by numerous researchers involved in many different clinical contexts. Considering the crucial role exerted by Gal-3 in many different clinical conditions, Gal-3 is emerging as a new diagnostic, prognostic biomarker and as a new promising therapeutic target. The current review aims to extensively examine the studies published so far on the role of Gal-3 in all the clinical conditions and diseases, listed in alphabetical order, where it was analyzed http://www.mdpi.com/1422-0067/19/2/379 and https://www.lifeextension.com/magazine/2004/3/report_citrus Plenty of other research: https://dreliaz.org/research/galectin-3-research/

This study demonstrated that aldosterone could induce galectin-3 secretion in vitro and in vivo (which occurs as part of the stress response so stressors increase galectin-3) https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4152338/

Galectin-3 (Gal-3) is an important regulator of fibrosis that links chronic inflammation to fibrogenesis. https://journals.lww.com/ASMR/Fullt...tiva_seed_reduced_galectin_3_level_and.2.aspx

 

[LINE]

This study demonstrated that aldosterone could induce galectin-3 secretion in vitro and in vivo (which occurs as part of the stress response so stressors increase galectin-3) https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4152338/

Galectin-3 (Gal-3) is an important regulator of fibrosis that links chronic inflammation to fibrogenesis. https://journals.lww.com/ASMR/Fullt...tiva_seed_reduced_galectin_3_level_and.2.aspx

Interesting about the aldosterone connection - my adrenal hormone profile was wildly out of control years ago when the CFS was out of control. Aldosterone was 2x normal levels.

- Adrenal activity is closely associated with immune activity I would suspect due to the needed boost the adrenal hormones assist in dealing with a chronic infection. As a side note, the other hormones were skewed as well, though oddly, cortisol was within normal range.

 

[godlovesatrier]

I'm about to start this due to increasing bacteroides and an absence of tart foods that I'm not allergic to in my diet. Doubt it's going to stop my cfs from flaring but good to know that it might be useful.

 

[lyran]

@LINE Do you take PectaSol as capsules or as a powder? It seems to be very expensive, 90 capsules costs 44€ in iHerb and you need to take 6 capsules a day so one jar lasts only 15 days.

 

[datadragon]

@Line Do you take PectaSol as capsules or as a powder? It seems to be very expensive, 90 capsules costs 44€ in iHerb and you need to take 6 capsules a day so one jar lasts only 15 days.

I will add/mention that PectaCLEAR is the one you normally are after since it has both the Pectasol-C that mobilizes, and the addition of seaweed-derived alginates, which work to inhibit re-absorption of the metals and toxins in the digestive tract, without which can cause symptoms of detox unless you dont have a metal issue and just being used for inflammation, fiber source etc https://wellbeinggps.com/products/pectaclear-detox-formula

The cheaper way (in using for longer than a few weeks) I did it was using Pectasol-C power along with separate algin which is key when there is known metal toxicity. For mainly detox use, I later found acz nano extra strength to be helpful without some of those detox issues when using too much or too often. I did not need the algin with acz nano. So that may help some people who read this later. Its also a source of fiber I should have mentioned that can increase short chain fatty acid levels (unless your in a late state with low acetyl-coa needed to convert to butyrate for example).
https://onlythebestherbs.com/Products/Algin/index.html
https://wellbeinggps.com/products/acz-nano-extra-strength
https://wellbeinggps.com/search?type=product&q=pectasol

 

[LINE]

@LINE Do you take PectaSol as capsules or as a powder? It seems to be very expensive, 90 capsules costs 44€ in iHerb and you need to take 6 capsules a day so one jar lasts only 15 days.

I tried the powder since it was more cost effective. I noticed some benefit within 2 weeks I would estimate. I was tempted to buy Swanson's MCP which is more cost effective but reasoned the more expensive product would remove doubts about MCP effectiveness.

I did not have any detox reactions as @datadragon mentioned but I also have used metal chelators for many years prior (which included ACZNano - which is a good product btw). I also used many other products for chelation which was very helpful.

I have also used these enzymes

https://amzn.to/3OnNlqa

https://amzn.to/3Q8ebUw

The purpose of this was to address biofilms which can be problematic. The research indicates that biofilms and the microclotting are related, so it was a double whammy for me. Total cost was around $120 for all 3 items and like I said, 2 weeks would be a window to know if it is helping.

 

[LINE]

This is a video I made about Gal 3 and MCP

I also made a video series on YouTube about biofilms.

https://youtube.com/playlist?list=PLA9aaXOpxIE3csmVpKKqi4NShxs3RKOXM

This sums up my most current knowledge of biofilms. I apologize for the unprofessional editing of the videos.

Of interest, the video at the top of this page (Dr. Eliaz), it is mentioned that MCP has ability to degrade LPS bacteria which for those who do not know, are a grouping of bacteria that are notorious for causing problems. They are resistant and create lots of inflammation.

 

[godlovesatrier]

For those in the UK TIME do a cheaper brand. You can take two caps a day for £23 a month.

 

[godlovesatrier]

https://timehealth.co.uk/product/modified-citrus-pectin/

 

[splusholia]

I’m going to try the Time brand—will report on how it goes…

 

[godlovesatrier]

Yes I won't get my test results for 4 to 8 weeks to see if it worked on bacteroide reduction. But as for my ME it gave me brainfog and some fatigue, which I am hoping will resolve in a few days, I am going to take it in the evening to prevent those symptoms intefering with work. It's 1.2g for 2 pills per day tho which is not a bad dose I think.