pattismith
Senior Member
- Messages
- 3,947
Impairments in cognitive performance in chronic fatigue syndrome are common, not related to co-morbid depression but do associate with autonomic dysfunction
Lucy J. Robinson,
Peter Gallagher,
Stuart Watson,
Ruth Pearce,
2019
Lucy J. Robinson,
Peter Gallagher,
Stuart Watson,
Ruth Pearce,
2019
- Result
- Cognitive performance in unselected CFS patients is in average range on most measures. However, 0–23% of the CFS sample fell below the 5th percentile. Negative correlations occurred between depressive symptoms (HAD-S) with Digit-Symbol-Coding (r = -.507, p = .006) and TMT-A (r = -.382, p = .049). In CFS without depression, impairments of cognitive performance remained with significant differences in indices of psychomotor speed (TMT-A: p = 0.027; digit-symbol substitution: p = 0.004; digit-symbol copy: p = 0.007; scanning: p = .034) Stroop test suggested differences due to processing speed rather than inhibition.
Both cohorts confirmed relationships between cognitive performance and HRV (digit-symbol copy (r = .330, p = .018), digit-symbol substitution (r = .313, p = .025), colour-naming trials Stroop task (r = .279, p = .050).
Conclusion
Cognitive difficulties in CFS may not be as broad as suggested and may be restricted to slowing in basic processing speed. While depressive symptoms can be associated with impairments, co-morbidity with major depression is not itself responsible for reductions in cognitive performance. Impaired autonomic control of heart-rate associates with reductions in basic processing speed.
- Fatigue in chronic hepatitis B patients is significant and associates with autonomic dysfunction
- 2019
- Background
Fatigue is an important clinical finding in patients with chronic hepatitis virus infection. However, studies assessing fatigue in patients with chronic hepatitis B (CHB) are very limited. This study aimed to quantify the severity of fatigue in patients with CHB, to determine whether perceived fatigue reflects impairment of functional ability, and to explore potential causes.
Methods
A total of 133 patients with histologically proven CHB and 59 community controls were assessed using the fatigue impact scale (FIS).
Results
The degree of fatigue was significantly higher in patients with CHB than in controls (mean (range) FIS 24.9 (0–91) vs. 15.7 (0–31), p < 0.001). Fatigue experienced by patients with CHB was similar to that in primary biliary cirrhosis (PBC) (n = 20) (FIS 22.2 vs. 20.9, p = 0.28). No association was found between FIS and biochemistry and histological parameters of liver disease severity. Significant associations were found between fatigue severity and cognitive impairment (r = 0.39, p < 0.001), daytime somnolence (r = 0.32, p < 0.001), scores of the Chronic Liver Disease Questionnaire (r = − 0.31, p < 0.001), and autonomic symptoms (r = 0.43, p < 0.001). The level of autonomic symptom was the only factor independently associated with the degree of fatigue.
Conclusion
Fatigue is a significant problem of functional ability impairment in CHB and similar in degree to that in PBC patients.
- Fatigue in patients with CHB appears to be unrelated to the severity of liver disease but is associated with significant autonomic sympto
Fatigue in Multiple Sclerosis is related to relapses, autonomic dysfunctions and introversion: A quasi-experimental study
Author links open overlay panelKatrinHankenaCarinaSanderbdHans-PeterSchlakebAndreasKastrupaPaulElingcHelmutHildebrandtad
https://doi.org/10.1016/j.msard.2019
Only patients suffering from a relapse showed a significant increment in fatigue from t1 to t2.- Regression analyses revealed that autonomic dysfunctions and introversion best explained the fatigue level.
Conclusions
This study shows that a relapse is accompanied by an increase in MS-related fatigue - . Moreover, autonomic dysfunctions and introversion, more than depression and apathy, play a major role in the explanation of MS-related fatigue.
- This finding represents additional evidence for the relationship between inflammation, vagal afferent signaling, autonomic dysfunctions, introversion and the feeling of MS-related fatigue.
Last edited: