COVID-19 accelerates 'zombie' cells in brain, Queensland study finds

[SWAlexander]

Excerpt:
COVID-19 has accelerated the presence of "zombie or senescent cells" that naturally accumulate as the brain gets older, according to a new Queensland study.
Researchers used synthetic brain organoid models "grown in a laboratory from human stem cells" to study COVID-19's effect on brain tissue.
Despite the negative findings, a way to reverse this cellular process was found by researchers at the University of Queensland's Australian Institute for Bioengineering and Nanotechnology.

Researcher Julio Aguado said the study gave confirmation that "COVID-19 was a catalyst for this premature ageing prompted an attempt to reset the biological brain clock".
"We used the brain organoids to screen a range of therapeutics, looking for any capable of removing those senescent cells," Aguado said.
The research found four drugs, navitoclax, ABT-737, fisetin and a cocktail of dasatinib plus quercetin (D+Q), eliminated the cells caused by COVID-19.
More at:https://www.9news.com.au/national/u...ie-cells/237a23c3-be37-48e6-99f4-5c0978015039

 

[Wishful]

Fisetin is something I've tried. No effect.

 

[SWAlexander]

I tried quercetin (D+Q), which is also in Vedicinals 9.
I helped quite a bit. However, I cannot take it for long.

 

[L'engle]

I'm taking quercetin but haven't tried or heard of any of the others. Quercetin is improving brainfog by a noticeable amount but still a long way to go.

 

[L'engle]

Fisetin is available on iherb:

https://ca.iherb.com/pr/doctor-s-be...ZG4aAvN1EALw_wcB&gclsrc=aw.ds#product-reviews

 

[Rufous McKinney]

Life Extension makes this product which contains Fisetin and Quercetin.

My husband was buying all this stuff. I took them, a few times and can't recall anything yay or nay.

https://www.lifeextension.com/vitamins-supplements/item02301/senolytic-activator


I take quercetin fairly regularly (for me). I think its reducing some of the allergic, but I can't verify that definitively, either.

 

[Alvin2]

There was an interesting article on Life Extension on Quercetin.
I had dug into it and it is a bit hyped so don't take the article at face value.

https://www.lifeextension.com/magazine/2015/ss/sweep-away-senile-cells

 

[SWAlexander]

I gave my friend Vedicinals 9 as a gift and one of the ingredients is Quercetin.
I researched all the ingredients.

The benefit of Quercetin and for what

Quercetin is a flavonoid found in a wide range of fruits, vegetables, and grains. It's one of the most extensively researched plant compounds, and numerous studies have explored its potential health benefits. Here are some of the suggested benefits and uses of quercetin based on scientific evidence:

Antioxidant Properties: Quercetin can neutralize free radicals, which can contribute to oxidative stress, cellular damage, and the progression of various diseases.

Anti-inflammatory Effects: Quercetin has shown the potential to reduce inflammation, which is implicated in many chronic diseases, by influencing various inflammatory pathways.

Heart Health: Several studies suggest that quercetin can help lower blood pressure and improve overall cardiovascular health. Its antioxidant and anti-inflammatory effects might contribute to these cardiovascular benefits.

Antiviral Properties: Quercetin has demonstrated antiviral activity against a range of viruses, including respiratory viruses.

Allergies: Quercetin can stabilize mast cells and reduce the release of histamine, which might help alleviate allergy symptoms.

Neuroprotective Effects: Some research indicates quercetin may offer protection against neurodegenerative diseases like Alzheimer's and Parkinson's by inhibiting inflammation in the brain and protecting neurons.

Supporting Athletic Performance: There's some evidence suggesting quercetin can enhance endurance and performance in athletes, potentially due to improved mitochondrial function.

Anticancer Potential: Quercetin has shown promise in inhibiting the growth and spread of cancer cells in laboratory settings. It may also make cancer cells more susceptible to chemotherapy.

Chronic Prostatitis/Chronic Pelvic Pain Syndrome: Some studies indicate that quercetin might provide relief from symptoms of chronic prostatitis or chronic pelvic pain syndrome.

Lung Health: Quercetin might help in reducing symptoms of chronic obstructive pulmonary disease (COPD) and asthma due to its anti-inflammatory properties.

Liver Health: There's preliminary evidence suggesting quercetin might protect the liver from certain toxins and help in conditions like non-alcoholic fatty liver disease (NAFLD).

Blood Sugar Regulation: Quercetin may have potential benefits in managing or preventing diabetes by improving insulin sensitivity and reducing blood sugar levels.

While quercetin exhibits numerous potential health benefits in laboratory and animal models. The bioavailability of quercetin can be quite low, meaning that it might not be efficiently absorbed into the bloodstream when consumed. However, certain formulations, such as quercetin phytosome, aim to improve its bioavailability.

 

[Wishful]

Notice the use of "can" and "may" and "might" and "some evidence (maybe from small poorly done studies)". I don't see any definitive studies showing that "3 capsules a day = 23% reduction in insulin needs" or anything like that. "This product <may> improve your health! Buy it now!!!"