Any studies carried out on triggered PEM me/CFS sufferers?

[Guwop2]

PEM occurs in me quite predictably after certain activities, (and arguably the main issue i suffer from) and I was curious what studies had been done that involve triggering PEM in individuals with ME/CFS and doing tests while this occurs to see what is happening/causing it. It's maybe an obvious thing to do, but I'm just not familiar at all with any theories or studies that point to reasons for its occurrence.

 

[Wishful]

Yes, it is obvious, and the not-obvious question is why there haven't been more studies about it. For some PWME it's a reliable response without long-term harm, so why not do some before/during/after studies?

 

[Guwop2]

Yes, it is obvious, and the not-obvious question is why there haven't been more studies about it. For some PWME it's a reliable response without long-term harm, so why not do some before/during/after studies?

Right, well im both surprised and not surprised. Perhaps there are reasons why it is not seen as something worth pursuing whilst other studies have been?

 

[Mimicry]

There are a lot of studies that are specifically designed to find out what happens during PEM, including some very interesting ones that were published earlier this year! Right now I don't have the brainpower to go through the findings but there 's an excellent post on Health Rising about some of them: https://www.healthrising.org/blog/2...mune-system-letdown-chronic-fatigue-syndrome/

 

[Guwop2]

thanks @Mimicry , just read it. Interesting -

"The problem appears to be less that ME/CFS patients’ systems are responding in strange ways to exercise than that they’re not responding at all."

NK Cells stuff is also v interesting..though are arent NK Cells like the 'microbiome', in that we know virtually nothing about it or how to manipulate it in a controlled way?

 

[Mimicry]

thanks @Mimicry , just read it. Interesting -

"The problem appears to be less that ME/CFS patients’ systems are responding in strange ways to exercise than that they’re not responding at all."

NK Cells stuff is also v interesting..though are arent NK Cells like the 'microbiome', in that we know virtually nothing about it or how to manipulate it in a controlled way?

Unfortunately I don't know much about the immune system, I'm still learning this stuff myself.

Here's another summary of a recent study written by Cort Johnson, I just got around to reading it myself
https://www.healthrising.org/blog/2...-exertional-malaise-chronic-fatigue-syndrome/

 

[hapl808]

Unfortunately I don't know much about the immune system,

As far as I can tell, neither do physicians. So you're in good company.

 

[Guwop2]

As far as I can tell, neither do physicians. So you're in good company.