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    Created in 2008, Phoenix Rising is the largest and oldest forum dedicated to furthering the understanding of, and finding treatments for, complex chronic illnesses such as chronic fatigue syndrome (ME/CFS), fibromyalgia, long COVID, postural orthostatic tachycardia syndrome (POTS), mast cell activation syndrome (MCAS), and allied diseases.

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endothelial dysfunction

  1. SWAlexander

    Microvascular Capillary and Precapillary Cardiovascular Disturbances Strongly Interact to Severely Affect Tissue Perfusion and Mitochondrial Function

    Pre print Approved: 12 December 2023 Myalgic Encephalomyelitis/Chronic Fatigue Syndrome (ME/CFS) is a frequent, debilitating and still enigmatic disease. There is a broad overlap in the symptomatology of ME/CFS and the Post-COVID Syndrome (PCS). A fraction of the PCS patients develops the full...
    • SWAlexander
    • Thread
    • capillary ischemia-reperfusion dysfunction by inducing sodium- and calcium-overload in skeletal muscles endothelial dysfunction mitochondrial dysfunction
    • Replies: 9
    • Forum: Latest ME/CFS Research
  2. O

    Endothelial dysfunction in Long-Covid measured by RVA correlates with symptom severity and inflammation

    Measurements and main results PCS patients exhibit persistent endothelial dysfunction (ED), as indicated by significantly lower venular flicker-induced dilation (vmax; 3.42% ± 1.77% vs. 4.64 % ± 2.59%; p = 0.02), narrower central retinal artery equivalent (CRAE; 178.1 [167.5 - 190.2] vs. 189.1...
  3. O

    Sulodexide (Aterina) experiences

    Does anybody have any experiences with Sulodexide (Aterina) to address endothelial dysfunction, it’s sort of an oral version of heparin? (Of course this isn’t a cure, but possibly a drug to add on top of the usual stack). I've heard from his patients that Dr. Laubscher, who's the clinical...
    • Osaca
    • Thread
    • coagulation endothelial dysfunction viral reactivation
    • Replies: 0
    • Forum: General ME/CFS News
  4. SNT Gatchaman

    Endothelial dysfunction in ME/CFS patients (Sandvik, Mella, Fluge et al, 2023)

    Endothelial dysfunction in ME/CFS patients Sandvik MK, Sørland K, Leirgul E, Rekeland IG, Stavland CS, Mella O, Fluge Ø Objective: A few earlier studies have found impaired endothelial function in patients with Myalgic Encephalomyelitis/Chronic Fatigue Syndrome (ME/CFS). The present study...
  5. C

    Serum of Post-COVID-19 Syndrome Patients with or without ME/CFS Differentially Affects Endothelial Cell Function In Vitro (Flaskamp et al, 2022)

    Abstract A proportion of COVID-19 reconvalescent patients develop post-COVID-19 syndrome (PCS) including a subgroup fulfilling diagnostic criteria of Myalgic encephalomyelitis/Chronic Fatigue Syndrome (PCS/CFS). Recently, endothelial dysfunction (ED) has been demonstrated in these patients, but...
    • Consul
    • Thread
    • angiogenesis autoantibodies endothelial dysfunction flaskamp nitric oxide pcs scheibenbogen
    • Replies: 3
    • Forum: Latest ME/CFS Research
  6. SWAlexander

    Endothelial dysfunction and altered endothelial biomarkers in patients with post-COVID-19 syndrome and chronic fatigue syndrome (ME/CFS)

    Abstract Background: Fatigue, exertion intolerance and post-exertional malaise are among the most frequent symptoms of Post-COVID Syndrome (PCS), with a subset of patients fulfilling criteria for Myalgic...
  7. C

    Endothelial dysfunction and altered endothelial biomarkers in patients with post-COVID-19 syndrome and chronic fatigue syndrom... (Haffke et al, 2022)

    Endothelial dysfunction and altered endothelial biomarkers in patients with post-COVID-19 syndrome and chronic fatigue syndrome (ME/CFS) Haffke et al, 2022 Authors: Milan Haffke, Helma Freitag, Gordon Rudolf, Martina Seifert, Wolfram Doehner, Nadja Scherbakov, Leif Hanitsch, Kirsten Wittke...
  8. C

    Letter: Could endothelial dysfunction and vascular damage contribute to pain, inflammation and post-exertional malaise in individual... (Lubell, 2022)

    Letter: Could endothelial dysfunction and vascular damage contribute to pain, inflammation and post-exertional malaise in individuals with myalgic encephalomyelitis/chronic fatigue syndrome (ME/CFS)? By Jeffrey Lubell Link...
  9. mitoMAN

    Decreased NO production in endothelial cells exposed to plasma from ME/CFS patients

    Decreased NO production in endothelial cells exposed to plasma from ME/CFS patients R Bertinat et al. Vascul Pharmacol. 2022. https://pubmed.ncbi.nlm.nih.gov/35074481/ Myalgic encephalomyelitis/chronic fatigue syndrome (ME/CFS) is a debilitating disease characterized by severe and persistent...
  10. Pyrrhus

    Persistence of SARS-CoV-2 Spike Protein in Long Covid up to 15 Months Post-Infection (Patterson et al., 2022)

    Persistence of SARS CoV-2 S1 Protein in CD16+ Monocytes in Post-Acute Sequelae of COVID-19 (PASC) up to 15 Months Post-Infection (Patterson et al., 2022) https://doi.org/10.3389/fimmu.2021.746021 A publication by Bruce Patterson and colleagues, regarding findings in the blood from Long Covid...
  11. Pyrrhus

    Erectile Dysfunction as Dysautonomia

    :star:The more you know!:star: So, the parasympathetic branch of the autonomic nervous system is responsible for producing a penile erection (or vaginal lubrication) in response to stimulation. This means that if there is a problem with this part of the autonomic nervous system, one might...
  12. M

    What is the poor man's endothelial function test?

    We all know the poor man's tilt table test, but is there an equivalent for endothelial function? The most usual way to measure endothelial function is via the Flow Mediated Dilation (FMD) test. It is not a high-tech test, but it tends not to be easily available either (not sure why). I am...
  13. SNT Gatchaman

    An attempt to explain the neurological symptoms of Myalgic Encephalomyelitis/Chronic Fatigue Syndrome (2021, Wirth et al)

    An attempt to explain the neurological symptoms of Myalgic Encephalomyelitis/Chronic Fatigue Syndrome Klaus J. Wirth, Carmen Scheibenbogen and Friedemann Paul Link Full text link Abstract There is accumulating evidence of endothelial dysfunction, muscle and cerebral hypoperfusion in Myalgic...
    • SNT Gatchaman
    • Thread
    • carmen scheibenbogen cerebral blood flow cognitive dysfunction dysautonomia endothelial dysfunction intracranial hypertension sleep wirth
    • Replies: 37
    • Forum: Latest ME/CFS Research
  14. SNT Gatchaman

    Persistent endotheliopathy in the pathogenesis of long COVID syndrome

    Authors: Fogarty et al Published: 10th Aug 2021 DOI: 10.1111/jth.15490 Full Text: J Thromb Haemostat (open access PDF) ABSTRACT ESSENTIALS Ongoing endotheliopathy is a common finding in convalescent COVID-19 patients and is independent of the acute phase response. Plasma FVIII:C levels and...
  15. nerd

    The Latest Long Hauler Research From Dr. Bruce Patterson

    Since they finally seem to have their first paper published soon, this time for real, hopefully, I'd like to discuss this latest update. Their main point for the symptomology is angiogenesis and vasodilation. This also happens in MCAS and CFS/ME, though. This is why histamine-induced symptoms...
    • nerd
    • Thread
    • endothelial dysfunction etiology long covid long haulers monocytes novavax vaccines
    • Replies: 8
    • Forum: Long COVID and Coronavirus
  16. Pyrrhus

    Endothelial Dysfunction in ME

    I thought I'd start a thread to summarize discussions about the different types of endothelial dysfunction that might be found in ME. Please feel free to add to this thread as needed. What is "Endothelial Dysfunction"? Blood vessels are enclosed by a layer of cells called endothelial cells...