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zonulin -> leaky gut

Discussion in 'Addressing Biotoxin, Chemical & Food Sensitivities' started by Suzy, Feb 14, 2010.

  1. Suzy

    Suzy Guest

    I just watched this talk:

    http://www.autism.com/danwebcast/pro_videomp4.asp?mp4=dallas_2009_21_fasano&h=480&w=640&VID=24

    THe speaker says that zonulin results in leaky gut. He says the biggest stimulus is bacterial overgrowth. And the second largest stimulus is gluten.

    I thought maybe this was perhaps the caes if gluten was not broken down. But he then goes on to report on a study in rats showing that gluten resulted in elevated zonulin and an immune response to the gluten. Since the rats were healthy I assumed there was no issue in breaking down gluten. Unless they gave so much gluten the rats could not possibly break it down and the remainder stimulated the zonulin.

    He said this increased i mmune response occcurs in all of us, healthy or not.

    This is a little disturbing since gluten is so prevalent in our society.

    Anyways, I'd be interested in others thoughts.
  2. determined

    determined Senior Member

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    zonulin

    Thank you for providing this. I'm too busy to look at it now, but I do want to come down on the side of bacterial populations plaiying the biggest role here. For decades I had to avoid gluten religiously. Even small amounts would result in vomiting, GI bloating, etc. But now I eat it every day with no problem!! So I don't see it as a genetic issue, for me at least.
  3. Suzy

    Suzy Guest

    Hi there,
    There was a q&a later and he said that even though it does occur in all of us, most of us have controlled inflammation.

    So, it seemsif we have something else causing inflammation in the first place (metals, infections etc) then it would be a problem.

    I don'tknow much about your story but good for you to make that progress!
  4. busybee

    busybee Senior Member

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    Hi Suzy,

    Dannybex posted this study

    The release of zonulin from intestinal epithelial cells treated with gliadins was considerably lower when digested with VSL#3.

    I've seen zonulin mentioned alongside carnitine and butyrate and BH4 if you need anything else to google:D
  5. Frank

    Frank Senior Member

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    Europe
  6. determined

    determined Senior Member

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    butyrate

    When I was at my worst in terms of food intolerances, butyrate helped me quite a bit! I'm glad to see it mentioned here.
  7. cigana

    cigana Senior Member

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    Hi Suzy,

    Thankyou very much for posting this resource.

    From my understanding he was saying that zonulin is produced even in non-gluten-sensitive people in response to gluten, right? In that case it seems to me that all of us who are concerned about a leaky gut should cut out gluten even if we don't have a noticeable reaction to it...

    Cheers,

    Cig

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