Hi, Its my first post in this forum and I wish to thanks all the people who contribute with this community to help and sustain each other. My experience is as follows: I've experienced many years of wheat intolerance and maybe gluten. During my adolescence I felt weak, without much energy, and brain fogged. Now I'm 29 and things are going better. I switched to an healthy diet, gluten free, only vegetables, legumes, rice and mostly eggs and fish, and my skin symptoms, such dermatitis, have recessed a lot. I've gained more and more energy in 2 years, but with drawbacks and a lot of up and down. Carboydrates and sugars expecially have been a pain to handle, I've suffered from sugar cravings, and probably my insulin response was a bit messy, but now I can control that with a low carbo diet. Moreover I've tried to address some cognitive impairments with a lot of supplements these years, expecially memory and motivational issues. Lately I find to be very low in zinc, I suppose because some intestinal infiammation or malabsorptions. This observation started with my fingers, because the "half moon", the white part at the base of the nails made of zinc, was completely absent. I could add that I had a lot of costipation in the past, wich now I address almost completely with red salts, wich have some clay in it. Long story short, I started to take Zinc bisglycinate (44 - 66 mg) togheter with p5p (100mg) , and sometimes Nac and Milk thistle. My metabolism started to respond very well immeadiately after the first dose of zinc . In 2 days my motivation and my energy was raised to extreme level, I was almost overstimolated, I started to sleep only 7 hours or less at night and my thougts were racing and I had some problems to fall asleep too. I experienced a peculiar sensation in my head, like a pulsation or some pressure in the veins, that came up every time I took my zinc dose. I've been taking even high doses of vitamin C, like 3g per day, which its used for copper toxicity, and a lot of carrot juice for the vitamin A. My memory increased a lot too, and I feel like I've came back to life, emotionally more involved in everything I did. But this sort of magic lasted for about two weeks, and progressively, the symptoms started to be more subtle, and the mind racing a little difficult to handle, with no more cognitive improvement, so I've started to cut out the doses to the point, after two months, that I've stopped to take all the supplements. I've read a lot about Pyroluria, Copper toxicity and Methylation, but still I've not found a reason for this acute reaction wich now seems almost absent. Maybe I must address some other pathways? I've started even to feel a few more symtoms of cold hands and feet, which I had before taking any supplement but during the first period of regimen seemed to recess after every meal. I've started taking also some copper, because it could have been depleted during my zinc regimen, and could be that a tiny bit of the first zinc effect is back after a few days under this regimen. (30 mg of zinc and 2.5 mg of copper) Maybe someone can guess something about my experience? Or more specifically, suggest me some exams to take to try to sort out the causes (which could be mineral imbalance, thyroid or adrenal issues or metabolic deficiencies). Unfortunately I live in Italy, and I dont know if there any specific terapies that I can try to work it out. Thanks a lot in advance!