AVIVA Semi-Finals: National ME/FM Action Network is competing for $100,000
The National ME/FM Action Network in Canada is competing for $100,000 for biomedical research of ME and FM in the Aviva Community Fund contest. With thanks to all who helped, they made it through the first round of voting into the Semi-Finals.
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Yet another 23andme interpretation request. Thank you.

Discussion in 'General ME/CFS Discussion' started by mpw, Mar 12, 2014.

  1. mpw

    mpw

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    I hope this is the correct forum. Does anyone have thoughts on my results.

    A little background. CFS for 18 years. I do have a chronic infection and am pretty sure that's what's causing the CFS, but I wanted to see if any these results have any relevance to the CFS. I do not tolerate B complex (it's like being in a coma) supplements. I can only take 8.25mg of B6 and it seems that B12 also causes more fatigue. I haven't decided with 5-folate causes more fatigue or not. Will have to test that again. Although I am homozygous for the MTHFR A1298C mutation I do have elevated homocysteine levels. At 2000mg of folate my homocysteine is 9

    Thank you very very much for any insight.

    MTHFR 03 P39P +/+
    MTHFR A1298C +/+

    VDR Bsm +/+
    MAO-A R297R +/+
    MTRR A66G +/+
    MTRR A664A +/+

    COMT V158M +/-
    COMT H62H +/-
    BHMT-02 +/-
    CBS C699T +/-
    CBS A360A +/-
     
  2. Allyson

    Allyson *****

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    Australia, Melbourne
     
  3. Valentijn

    Valentijn Activity Level: 3

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    MTRR A66G means that you might benefit from B12 supplementation. Which form did you try before? MethylB12 causes some people problems, but other people need it.
     
  4. mpw

    mpw

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    Thank you so much for the reply. I was taking Methyl B12. I'm going to have to try it again. I was taking folate, B12 and B6 (all the active proper forms). Decided to drop them all, but I know I need to go back to the folate sooner rather than later. Perhaps I'll retry the B12 and folate without the B6 since I know for sure larger doses of B6 do cause more fatigue. I have never felt B12 make any difference in fatigue. I can't imagine it would in my state. Thank you again.
     
  5. Valentijn

    Valentijn Activity Level: 3

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    HydroxoB12 might make a difference as well, instead of MethylB12.
     
  6. mpw

    mpw

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    Thank you, I'll give that a try.
     

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