Hi, I'm Italian.. 30 years old..sorry for my english..maybe it's not so perfect . I have been suffering from erectile dysfunction and low sex drive for years. At the beginning, I thought it was related to topical Minoxidil, for hair loss (I have used it for 5 years). I started to find out what could help me... and so, up to now, I can say that: - methylcobalamin gives me little improvement; - B6 makes a great difference, causing a great improvement in libido and erection (both B6 and P5P); - B6 and zinc make greater improvement; - folic acid makes me impotent; - methylfolate, taken with methylcobalamin causes improvement for few days, then nothing; - methylfolate taken 24 hours after methylcobalamin (not taking mb12 that day) causes some degrees of improvement, not as B6 does. And after a few days, the improvement stops; - folinic acid, taken with B6 and zinc, cures me and restores optimal erections, but doesn't enhance libido in the same extent of erections. In addition folinic acid makes me relaxed.. great feeling! Unfortunately, in Italy we don't have any genetic test like the 23andme one .. So, what I'd like to ask you is: - what kind of snp could I have? - did someone have the same problems? - has someone treated this well? I think that my problem has to be connected with methylation or bh4 production. Other clues are: - precocius white hair; - great memory when I was a child-teen until 30 years, then it started to fade... but big improvement since I take b12 (methylcobalamin and/or adenosylcobalamin); - IBS and bloating since I was a child. What I'm doing right now is: - 5000 mcg mb12 and 2500 mcg adenosylb12 after I wake up; - 800 mcg methylfolate and 1250 mcg folinic acid in the afternoon; - 50 mg of P5P (I see that I feel better when I take it close to the folates); - zinc, 22 mg once or twice / day; - magnesium once per day; - betaine HCL at lunch and dinner, depending on how many proteins I have. It seems that the keys of the treatment are folinic acid and p5p, and to a lesser extent, zinc. What could it be???? I also thought that Minoxidil started a NO/ONOO loop on a pre-existing scenario of snp like MTHFR a1298c and MTR-MTRR. But these are only suppositions, because I can't do any test where I live! Has someone already suffered from this (low libido, weak erection, memory deterioration) and resolved it? Thank you so much, to everyone !!