I think this is the safest next route. There are some good roles for IgE, but it's not really a primary immune responder. Very small part of the immune system. Have no idea why this would work, except that I have high IgE, and allergies cause fatigue. Have allergies to dust mites. One or two anecdotal reports of it working for CFS. Elevated IgG Elevated IgE Low Plasma Dopamine High DHEA/Low FSH Obviously, elevated EBNA EA IgG to EBV. That's my profile. I've had over 50 blood tests for the common culprits of CFS, just assume they are negative, CMV, HHV (interesting), CPN, Lyme etc.