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Xmrv type viruses immunomodulation and neural infection

Discussion in 'XMRV Research and Replication Studies' started by Gerwyn, May 21, 2010.

  1. Gerwyn

    Gerwyn Guest

    Increased proinflammatory cytokine and chemokine responses and microglial infection following inoculation with neural stem cells infected with polytropic murine retroviruses(XMRV type Viruses)
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    Karin E. Petersona, Corresponding Author Contact Information, E-mail The Corresponding Author, Leonard H. Evansb, Kathy Wehrlyb and Bruce Chesebrob

    aDepartment of Pathobiological Sciences, School of Veterinary Medicine, Louisiana State University, Skip Bertman Dr., Baton Rouge, LA 70803, USA

    bLaboratory of Persistent Viral Diseases, Rocky Mountain Laboratories, National Institute of Allergy and Infectious Diseases, 903 South 4th Street, Hamilton, MT 59840, USA
    Received 13 April 2006;
    revised 22 May 2006;
    accepted 12 June 2006.
    Available online 27 July 2006.

    Abstract

    Proinflammatory cytokines and chemokines are often detected in brain tissue of patients with neurological diseases such as multiple sclerosis (MS), HIV-associated dementia (HAD) and Alzheimer's disease (AD). We have utilized a mouse model of retrovirus-induced neurological disease to examine how these proinflammatory responses contribute to neuropathogenesis. In previous studies with this model, a correlation was found between neurovirulence and cytokine and chemokine expression. However, it was unclear whether the induction of these cytokines and chemokines was in response to specific virus envelope determinants or was regulated by the level of virus infection in the brain. In the current study, we demonstrated that multiple polytropic retroviruses induced cytokine and chemokine mRNA expression following increased virus levels in the brain. Increased virus levels of polytropic viruses also correlated with increased neuropathogenesis. In contrast, the ecotropic retrovirus, FB29, did not induce cytokine or chemokine mRNA expression or neurological disease, despite virus levels either similar to or higher than the polytropic retroviruses. As polytropic and ecotropic viruses utilize different receptors for entry, these receptors may play a critical role in the induction of these innate immune responses in the brain.

    Keywords: Chemokines; Cytokines; Brain; Neuropathogenesis; Microglia; Retrovirus; Mouse
  2. sunlady

    sunlady Guest

    Good find Gerwyn, the vets are often way ahead of the medical doctors we deal with.

    Vets know of ME, it is similar to a virus that affects horses and there seems to be no problem for them in describing its existence.
  3. natasa778

    natasa778 Senior Member

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    London UK
    Sad but true. Also tragic that they are waaay ahead in terms of treatments for 'mysterious immune-related illnesses' in horses. Many of the things considered 'snake-oil' or still out there or too expensive to use by the mainstream are used routinely and successfully for horses... Things like transfer factors, hbot, magnetic field therapy, name it....

    I guess the health and well-being of money-making Thoroughbreds is taken much more seriously than the health of us mere mortal humans :(
  4. flybro

    flybro Senior Member

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    pluto
    Yes and it seems no problem getting a full body MRI scan for your prime sheep, as featured on BBC news this week.

    If only we were prime meat as oppossed to diseased 'past our sell by date' humans.
  5. Robin

    Robin Guest

    I can't find anything about that except some old case studies describing "CFS" in horses where they found bacteria present on red blood cells. It was treated with low doses of rat poison!

    There's equine encephalitis virus which can cause neurological symptoms and fatigue in horses, however it is fatal. Is that the virus you mean? It's spread through mosquitos and can also affect people! There's also equine herpes virus which can cause respiratory symptoms and weakness, is untreatable and can reoccur. Poor horsies!

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