Nat Genet. 2002 Feb ;30 (2):221-6 11818964 Cit:39 Increased insulin sensitivity despite lipodystrophy in Crebbp heterozygous mice. [My paper] Toshimasa Yamauchi, Yuichi Oike, Junji Kamon, Hironori Waki, Kajuro Komeda, Atsuko Tsuchida, Yukari Date, Meng-Xian Li, Hiroshi Miki, Yasuo Akanuma, Ryozo Nagai, Satoshi Kimura, Takeyori Saheki, Masamitsu Nakazato, Takeshi Naitoh, Kenichi Yamamura, Takashi Kadowaki TAKE HOME MESSAGES XMRV BINDS WITHIN THE CREB GENE.. OK WHAT DOES THAT MEAN Mitochondria are our batteries that generate the power that our body systems need to operate properly The easiest way to visualise the action of CREB is like a switch in a circuit. If the switch is off even though the battery is fully charged no current can flow and no work can be done.Once the switch is turned on(CREB phosphorylated by ATP) the various biosystems in the body power up in a controlled way. If one other other hand XMRV becomes integrated the switch can become faulty .This can cause "short circuits" or power cuts or turning on and off at the wrong times. It is a bit like every electric household item going crazy throwing sparks teely picture going on and off miccrowave bleeping etc The other message to take from the paper is that CREB regulates the production of sterols. The most commonly known sterol is cholesterol whose levels are frequently elevated in people with ME.Sterols are also the "reenforced concrete" of our cellular structures. Defects in their production could theoretically end up with "Leaky" cell walls just about everywhere particularily in the gut.