My understanding is that this is the reason the pol gene is often used for detection in retroviral research. However WPI did not use pol and claims there is very little mutation of XMRV. So therefore they used gag and in one replication they used env. So I'm not sure how your comments connect to this specific XMRV finding...if XMRV is slow mutation. Also, the problems with degredation are apparently manageable as positives are being found by VIP Dx with samples shipped overnight. That is an interesting name idea. MELAS does not sound like CFS, since it is actual dementia and not just brain fog. But one thing is for certain, CFS is not a 'syndrome', I would call it some type of spectrum disorder. ME fits in the spectrum along with probably a dozen other conditions.