1. Patients launch $1.27 million crowdfunding campaign for ME/CFS gut microbiome study.
    Check out the website, Facebook and Twitter. Join in donate and spread the word!
Nitric oxide and its possible implication in ME/CFS (Part 1 of 2)
Andrew Gladman explores the current and historic hypotheses relating to nitric oxide problems in ME/CFS. Part 1 of a 2-part series puts nitric oxide under the microscope and explores what it is, what it does and why it is so frequently discussed in the world of ME/CFS. Part 1 focuses...
Discuss the article on the Forums.

XMRV. One virus or more subtypes??

Discussion in 'XMRV Testing, Treatment and Transmission' started by Solon, Oct 31, 2009.

  1. Solon

    Solon Guest

    I think soon XMRV 1 and 2 and probably 3 and more will be discovered and differentiated. Its impossible that all those different CFS immune profiles (low NK cells in some, low CD4 in otheres, low CD8, low monocytes or combinations of those etc etc) are brought about by a single XMRV agent- unless the persons immune response is so variable (hmm doubt it too, since whole families exhibit similar profiles).
    Unless the co-infection with EBV,CMV, HHV6, enteroviruses, and other common pathogens changes the picture so much (which could be possible with current research) but deeply inside i think there has to be some more similar gamma-retroviral agent(s) that play a role. We just have to wait for it to get discovered. HepatitisA-E, Hiv1-2-0, HTLV1-2, Herpes1-8 are typical examples of multiple viral pathogens causing in most cases similar disease or not??

    Can history be proven wrong in this case?? Time will tell i guess
     
  2. Summer

    Summer Senior Member

    Messages:
    175
    Likes:
    0
    Think of polio and all the presentations. The same with HIV, or even the flu. No one with any disease presents exactly the same. The researchers have been pretty clear they are finding XMRV without what might be called classic immune findings in many XMRV/CFS patients, but they have XMRV.
     
  3. Solon

    Solon Guest

    You think one and only XRMV type then?? That would be the most optimal ..
     
  4. Summer

    Summer Senior Member

    Messages:
    175
    Likes:
    0
    See this article:

    Is a Virus the Cause of Fatigue Syndrome?


     
  5. Mark

    Mark Acting CEO

    Messages:
    4,528
    Likes:
    2,004
    Sofa, UK
    I think it's perfectly plausible that XMRV can cause widely differing effects in different people, without needing multiple variants of XMRV to explain those differences. In my case, my main immune dysfunctions are extreme amplifications of allergies that I know run in my family already. So XMRV might undermine the immune system in general, and the way that plays out depends on your individual immune profile (which would be genetically linked so would explain the similar symptoms in family groups).

    Also, XMRV can infect a wide variety of cells, and I think somebody at the CFSAC meeting asserted that it might spread to the heart after a few years, then a few years later to the brain, etc. So there may be an element of chance as to which systems happen to be infected with XMRV, and therefore different symptoms result.

    That said, I also think it's likely that there will indeed turn out to be other variants of XMRV out there, and indeed other infectious retroviruses that are spreading and causing either CFS-related symptoms or other illnesses. That's why I think it's so important that when the dust settles and we find out who's X+ and who's X-, we all take very seriously the possibility that the X- PWCs have another retrovirus that hasn't been found yet. For me the big aim for society to get out of all this is: more openness from science and medicine to the idea that there are many things they do not yet know, and therefore much more compassion for those whose chronic illnesses remain explained.
     

See more popular forum discussions.

Share This Page