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XMRV: Necessary but not sufficient?

Discussion in 'XMRV Research and Replication Studies' started by richvank, Nov 12, 2009.

  1. gracenote

    gracenote All shall be well . . .

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    double-blind study

    From the article Chronic Fatigue and Prostate Cancer: A Retroviral Connection by Sam Kean
    Isn't this what we all are hoping will happen? Isn't this what is needed to move this research to the next step? I hope someone, somewhere is trying to do this now. I don't know that we need to characterize DeRisi as someone protecting his turf/discovery, at least based on this one statement.
    ----------
    According to what Kurt just posted above, it looks like many someones, somewheres, are already beginning these studies.
  2. jenbooks

    jenbooks Guest

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    Suggesting her results could be due to contamination is an insult and I read it as protecting his turf and not wanting her to steal his thunder.
  3. gracenote

    gracenote All shall be well . . .

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    okay, got it

    Jenbooks said:
    Okay, I guess I just passed over this part: "And the Mikovits team didn't do enough to rule out contamination, he [DeRisi] says." I get it. That makes sense.
  4. George

    George Guest

    Thanks for posting that Kurt. I've been searching daily for research. study's, or information about who is doing what. They really are all very low key about this. I am keeping my fingers crossed for a confirmation of XMRV in a significant percent of PWC's.
  5. _Kim_

    _Kim_ Guest

  6. kurt

    kurt Senior Member

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    Singh found no RNasL connection !!!!! ????

    WOW, thanks for pointing that out. Am I reading this correctly? Looks like Singh found no RNAsL connection in her study!!!???

    Here is the abstract:

  7. _Kim_

    _Kim_ Guest

    Kurt, that is an Open Access article. You can read the full text from the link below.

    XMRV is present in malignant prostatic epithelium and is associated with prostate cancer, especially high-grade tumors

  8. _Kim_

    _Kim_ Guest

  9. Martlet

    Martlet Senior Member

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    My guess would be yes, too. I was traveling out West when I got sick and a tick bite was certainly possible. I remember they tested me for Rocky Mountain Spotted Fever, in an attempt to rule things out.

    That said, I had a dog, while one friend had a dog and guinea pigs and another had a cat, so fleas also sound like a very possible vector.

    And if the virus was already in the human population, the flea or tick could transfer it straight from person to person, without needing a mouse.
  10. Marylib

    Marylib Senior Member

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    "Mystery illnesses" throughout history

    I am no scholar...but it is interesting to speculate how many illnesses have turned out to result from infection. The "plague," (who would have thought it was the flea bites from the rats?), tuberculosis, stomach ulcers, you name it.
    I think one day we will look back at ME/CFS as one of those, won't we? And someday perhaps, the intervention of psychiatry in this illness will be likened to the practice of "casting out spirits" to cure the ill.
  11. George

    George Guest

    XMRV is not a new new illness

    HIV entered the Human Gene pool between 1890 and 1915 it took around 70 years for it to become a pandemic. Remember it's passed on via sexual secretions and blood like XMRV.

    The XMRV virus likely entered the population between 1910 and 1930. It's not a new new illness. Most researchers in the CFS field put the first epidemic at 1934 in LA General Hospital.

    If you have more or less the same time frame for spread in the population, roughly70 years, then the 80's and 90's would be when it became to "big" to be ignored. Enough people have the virus at this point that like HIV it's a pandemic.

    If you want to follow the ideology that I state above please look in the General section under the question about outbreaks.Warning! It's a really long read( big grin)
  12. George

    George Guest

    Right on

    Hey Marylib you got it right on. My daddy died from all of the stomach surgeries. He had ulcers that kept bleeding. So the doctors took out more and more of his stomach. He died at the age of 53 from malnutrition. That was in 1986. The doctors hounded him about "being positive", "not stressing" and other things that they believed at the time caused ulcers. Not 5 years later some smart doctors said, "wow, look at that it's a bacteria that caused the problem, not worry like we use to think"

    Sheesh! And this happened in my life time. So it's not really unusual what's happening with us. It's part of pattern that really does go back to casting out demons like you say. We can be a superstitions lot sometimes.

    Sometimes I wonder if the Psychiatrist are really twisted people who can't separate from their egos long enough to do "pure science". They are too busy needing to be right.
  13. Marylib

    Marylib Senior Member

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    For George

    Certainly I feel psychiatrists have not been helpful in treating ME/CFS..and even in some cases have possibly done great harm, but I sure can't label them all as egotists.
    I actually was sent to the psychiatrist before being diagnosed properly (by our wonderful NZ specialist, Dr Ros Vallings). The GP thought I had depression, of course.
    It worked out okay for me, because I needed some kind of sleeping medication rather desperately and the GP was of no help. The psychiatrist doc I saw was a sweet older gentleman who indeed gave me some sleeping medication, which helped alot. He gave me an antidepressant, which did not help. So I quit taking it. Pretty simple.
    Anyway, I liked him. I found him to be a sweet man who genuinely wanted to help me. Fortunately I was not severely ill, not in the UK, so was never in danger of being abused.
    Fortunately I eventually found Dr Vallings.
  14. Marylib

    Marylib Senior Member

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    For George

    Certainly I feel psychiatrists have not been helpful in treating ME/CFS..and even in some cases have possibly done great harm, but I sure can't label them all as egotists.
    I actually was sent to the psychiatrist before being diagnosed properly (by our wonderful NZ specialist, Dr Ros Vallings). The GP thought I had depression, of course.
    It worked out okay for me, because I needed some kind of sleeping medication rather desperately and the GP was of no help. The psychiatrist doc I saw was a sweet older gentleman who indeed gave me some sleeping medication, which helped alot. He gave me an antidepressant, which did not help. So I quit taking it. Pretty simple.
    Anyway, I liked him. I found him to be a sweet man who genuinely wanted to help me. Fortunately I was not severely ill nor in the UK, so I never had to endure what some people have experienced.
  15. dannybex

    dannybex Senior Member

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    So in other words, it's likely not very easy to "catch" it, even if you're just talking about the outbreaks. I would be curious to know where the you got the HIV information...even though HIV and XMRV are totally different retroviruses.

    d.
  16. kurt

    kurt Senior Member

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    ticks and retrovirus

    See the study abstract below. While the authors conclude that HIV transmission by ticks is unlikely, they demonstrated that the HIV retrovirus stays alive for up to 10 days inside the tick... XMRV is a much simpler retrovirus than HIV, so don't know if that means it is more or less likely to survive that long.

  17. George

    George Guest

    Hi
    You are right that they are very different retroviruses. I've been reading Dr. Coffins research on about a dozen different Murine Leukemia viruses. They are fascinating! No wonder this guy is interested in XMRV. Most of them are like you point out "not easy to catch". Most are blood born and don't survive long outside of that environment.

    Oh my primary source of the HIV origins information is from here but I have a couple of others as well if you are interested.

    http://www.avert.org/origin-aids-hiv.htm
  18. Advocate

    Advocate Senior Member

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    Hi George,

    That paper on the origins of HIV is very interesting. I think we have a lot to learn from HIV.
  19. Advocate

    Advocate Senior Member

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    Isn't it strange how two-thirds of the tests for the sick people were contaminated but less than 4% of the healthy control tests were contaminated?
  20. Alice Band

    Alice Band PWME - ME by Ramsay

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    Kurt,

    There is also a Spanish group to add to the list

    http://www.institutferran.org/fatiga_cronica.htm

    RESEARCH PROJECT

    Second validation of the presence of retrovirus XMRV in patients with Syndrome of serious Chronic Fatigue (Fukuda criteria and Canadian positives - certificates by an expert doctor, demonstrable neurocognitivo impact and tests of effort test-retest (24h) with fall superior to 25% in a second and minimum of an analytical alteration of immune profile), and healthy population.
    Selection of 100 patients and 100 healthy controls. Totally gratuitous study.

    The patients will receive their results two months after the extractions of the samples.

    More information: Mrs Lurdes Farreras (935522747). Beginning of the present study: January of 2010

    Note

    They say there is the possibility of testing for the XMRV Virus at their Institute but that the test is for the moment only experimental because there isn't enough scientific evidence that the test is reliable

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