Hi Eric, I'm surprised at you saying this coming as you do (like me) from a Chlamydia pneumoniae background. NAC can and does damage a significant number of chlamydial elemetary bodies, as witnessed by the intense reactions people get to it. In my case an increase in dosage feels like someone has poured gasoline down my oesophagus. There is also the distinct endotoxin reaction one gets - a sudden drop in body temperature that is quite unnatural. These brisk reactions are repeated with other disulphide-bond reducers such as DMPS. I don't know anything about XMRV disulphide bonds, but I do know that when I first saw a picture of the virions being released it reminded me of only one thing, namely Chlamydial elementary bodies. How well a chlamydia infection spreads and propagates will depend on how oxidizing the body is, since at the least it will determine how long the elementary bodies survive. I can only imagine that the same is true for XMRV. If so it provides a natural docking point for Rich's Methylation block theory.