Hi Guys, I'm sure this has been covered somewhere before, but I can't seem to find it. So apologies if I am repeating a previous post. What I cannot seem to understand with fog brained mind, is how exactly, XMRV is hypothesized to cause such a severe disease if the copy number is so low, like the WPI emphasize how hard X is to find in the blood because of its low copy number. And the studies in the Rheus Macquaques Monkeys shows a systemic infection that is initially high, but becomes quite low if I remember correctly. This study looked at virus in the tissues. Say if XMRV changes some of the genes in your DNA/RNA that are largely responsible for most of the biochemical changes known as Cfs/me. And the XMRV infection is a low copy number i.e. low viral load (say e.g. 10 out of every million cells are infected) How can this then induce such significant changes to protein expression? Say if for example, this is just to illustrate my point, that XMRV downregulates ATP synthase expression in the cells that it infects.. Then this could have a significant impact on the Respiration and consequent energy production of those cells, BUT not many are affected by this change... I've read that HIV viral load is one of the key considerations for when patients begin ARV treatment and this correlates with disease severity. So if XMRV only actually affects very few cells then you would think that it would not be able to have any significant affect on your health? Sorry if I have missed the point, I just really want to understand the hypothesis behind this?