Mij, 450 mg of tumeric with 50 mg of standardized extract to 95% curcumineroids taken twice daily 12 hours apart. Recommend preloading with standardized milk thistle first as the effect on fatigue and sleep quality is profound while doing the Marshall Protocol. Diesel, > You should publish it through a journal, great science by the way. Thanks! Having never completed a formal masters in science yet (I have a professional alternative health degree) I’ve never been published and am a little shy to do it-also I’m still in treatment with the CFS so have to deal with the brain fog and fatigue but should I make a good recovery using this protocol I’ll discuss publishing something with my MD. Daffodil, My vit 1,25D was 63 pg/ml which exceeds the high normal range. Marshall has criticized vit D testing methods at some labs for allowing it to degrade. He recommends using Quest labs (that’s the one I used). I’d say try a therapeutic probe by avoiding vitamin D for a few weeks with no food intake, supplements and light exposure, try to turmeric experiment in the other thread and see if it provokes your symptoms. If so then that’s a positive and indicates you would benefit from treatment. EnergyOL, > I think it is a bit odd how long some of the moderators seem to remain on the protocol. 2-3 years or more sometimes. This suggests it is not curative. I agree and have criticized the existing treatment here for not addressing all of the blocked pathways causing incomplete and slow treatment tolerance. > Also couldn't the L-form bacteria merely be infections secondary to XMRV/MLV induced immunodeficiency? If that were true then we should see good responses to antivirals which doesn’t happen. > If these L-forms were solely the cause of CFS wouldn't they get more consistent results with the mycoplasma testing? (this is L-form bacteria). Wouldn't they find like a good 90% of CFS people all have mycoplasma? Surely? No, there are many other species. It just depends on what was around at the time. Also, once one bug suppresses the immune system then others can infect so it would be progressive. > Please can you put me in touch with anybody out there who once had CFS who has now finished the Marshall Protocol and is now SIGNIFICANTLY better, and remains better without having to adhere any longer to any of the MP - i.e. no longer any sunlight avodiance, vitamin d avoidance, chronic benicar and antibiotic consumption? As I said before, I don’t think they are lying but I do think they make many mistakes due to being out of their field. I do think it is partially correct but needs to have additional supplements to work rapidly and completely. I would not recommend anyone do the MP without these modifications. If anyone is interested they can email http://www.chronicillnessrecovery.org/ who I have sent the protocol (ask for the BALI protocol by Allen Botnick DC). Jenbooks, The reason I take curcumin is because it unblocks the PI-3 pathway related to histamine in mast cells improving immune function.(Adori, M 2010) When I took this it gave a positive immunoprovocative response which is interpreted as showing effectiveness in bacterial killing. Because the minocycline is also immunosuppressing I take them together but have discerned that the silymarin is a required protectant and must be dose 1 hour prior to minimize curcumin’s NF-kB blocking. If another agent was available I would stop it immediately. Given that I don't have any other symptoms of estrogen overdose and avoid xenoestrogen sources I should be alright with it. Hopefully the antibiotics can Which species of bacteria are stimulated by estrogen? Do they have L forms? Silymarin definitely helps with the detox. I suspect what is happening is that the turmeric is exerting an antibacterial effect, releasing toxins as the mast cells degrade and the liver has to detox this or they inflame the system, causing nitric oxide overload and impairing mitochondrial energy synthesis which we feel as the symptoms of inflammatation and fatigue. If bacteria were strengthening then symptoms would improve, not needing sylymarin (milk thistle) and this doesn't happen to me. Actually milk thistle was the first supplement I tested and without turmeric it doubled my treatment rate by halving the cycle duration for the bacterial kill as reflected by low grade fever appearance and resolution. This was because it unblocked the NF-kB pathway. Ukx, I hope that the MP evolves, however Trevor Marshall is really hotheaded and not open to research. I think at the point he thinks he has a working treatment. Interesting information on the origins of the antibiotics. I wasn’t aware of that. I agree that he has no right to a modified protocol which is why I recommend the BALI protocol which is more accurate. Also be aware that Faherty's article on the extra pathways wasn't published until 2008. The MP originated in 2003 and Trevor Marshall has a strong bias against all supplements. Anyway, don’t assume this won’t work Ukx. It fits the data quite well and is worth a shot. What has anyone got to lose? Xrayspex, It is very likely there are a few different diseases under the same moniker CFS. The only way I know to tell if someone is L form compromised is by a therapeutic challenge and watching for inflammatory immunopathological symptoms and confirming this with increased vitamin 1,25D. This infection doesn’t lower natural killer cells so you appear to have another disease. Dysbiosis is easy to treat using supplementation so just find a competent to guide you through it and hopefully it will help. As for calcium it requires stomach acidity so consider whether you may be taking antiacids that are blocking the absorption. Calcium is a balance so avoid things that drain it like excess animal protein (which should be eaten in excess) and phosphates in diet soda. Everyone needs to eat green leafy vegetables which are high in calcium but given the low soil levels I always recommend a good chelated multimineral (I take Country Life Total Mins Iron-Free) at least in a half dose daily because that covers all the bases. Magnesium deficiency will also cause you to be deficient. Everyone, as a patient myself with CFS I am very critical of treatments. I just want to craft an effective treatment and get well myself. I am personally disabled with CFS and really need to recover. I do not profit financially by the BALI protocol I recommend. In reviewing the four supplements I endorse I had to screen 15 compounds and rejected most of them due to adverse effects.