Considering that 4% of healthy normal control subjects have XMRV virus researchers have stated that it likely is only a trigger or coinfection in chronic fatigue syndrome. Why then do patients here think that some kind of retroviral therapy will cure chronic fatigue? Seems like a wild goose chase. Instead, people should concentrate on finding and treating the culprits behind the lowered immunity rather than these opportunistic infections. http://chronicfatigue.about.com/b/2010/02/01/wpi-presentation-on-xmrv-chronic-fatigue-syndrome.htm http://www.forums.aboutmecfs.org/showthread.php?6935-XMRV-Low-Copy-Number I did some searching and found research showing that cytokines produce an excess of NO production and this inhbits mitochrondrial biogenesis. http://content.onlinejacc.org/cgi/content/full/35/5/1338 http://ajpendo.physiology.org/cgi/reprint/289/6/E1101 So a chronic infection with low grade inflammation would directly inhibit the growth of mitochrondria resulting in massive fatigue. This fatigue would be worsened while treating the bacteria but decrease as the bacterial numbers were lowered. Another thing I turned up is that isoflavones stimulate mitochondrial biogenesis (reproduction), although it probably wouldn't work if someone's NO is inhibited but maybe once the load is low enough. I am in treatment with a modified version of the Marshall Protocol for L-form bacteria. This treatment involves low dose antibiotics plus supplements to restore blocked apoptosis pathways. I have consistently observed that when my NK-FB pathway is blocked by taking turmeric without Milk Thistle protection I am twice as tired and require more naps than if it is protected. Even if XMRV lowers energy production, if the L-form cell wall deficient bacteria hypothesis is correct then eradicating the bacteria so the body doesn't have to mount a large scale defense spares energy and could be enough to return to a functional range. So this theory is hopeful that the mitochrondrial deficit may be curable.