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XMRV Induces Cell Migration, Cytokine Expression and Tumor Angiogenesis

Discussion in 'XMRV Research and Replication Studies' started by Jemal, Jul 28, 2012.

  1. Jemal

    Jemal Senior Member

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    http://www.plosone.org/article/info:doi/10.1371/journal.pone.0042321?utm_source=feedburner&utm_medium=feed&utm_campaign=Feed: plosone/Urology (PLoS ONE Alerts: Urology)
     
  2. Ember

    Ember Senior Member

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    This statement in the discussion may be worthy of note: “XMRV-induced cytokine release does not appear to be tumor epithelial cell specific...”
     
  3. currer

    currer Senior Member

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    Looks like the XMRV is ramping up the cancer.
     
  4. natasa778

    natasa778 Senior Member

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    London UK
    Yes. Impressive little ability considering xmrv is a recently created chance contaminant.

    I wonder how this links:

    IDENTIFICATION OF A NOVEL RETROVIRUS IN PATIENTS WITH BENIGN PROSTATIC HYPERPLASIA

    http://www.freepatentsonline.com/y2012/0107338.html

     
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  5. natasa778

    natasa778 Senior Member

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    oh btw (even though retroviruses couldn´t possibly be causing neuroimmune diseases :rolleyes: ) osteopontin is significantly raised in autism, and its levels correlate to severity of symptoms ...

     
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  6. currer

    currer Senior Member

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    (From the paper) -" mice naturally do not develop PC"

    anciendaze pointed this out on another forum.
    Looks as if the mice could be immune to whatever is causing the PC- (remember they have evolved to be without the xpr1 receptor.)
     
  7. currer

    currer Senior Member

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    "We provide evidence that the gammaretrovirus XMRV significantly contributes to tumorigenesis of 22Rv1 xenografts in mice. These observations are supported by in vitro results demonstrating differences in cytokine release in 22Rv1 cells infected with XMRV and 22Rv1 cells with reduced viral transcripts. Furthermore, we provide evidence that XMRV infection in prostate stromal fibroblasts significantly induces changes in cytokine release"
    ...."In summary, our results indicate that the transforming capacity of 22Rv1 cells is strongly dependent on the presence of XMRV. "
     
  8. currer

    currer Senior Member

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    "BPH virus: A retrovirus identified in prostate samples from subjects with BPH.The BPH virus is distinct (for example at the nucleic acid or amino acid level) from XMRV"

    From the above O'Keefe patent..(Thanks Nastasia.) Did we miss this patent when it was published? I dont remember it.
     
  9. currer

    currer Senior Member

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    From Wiki -
    "Osteopontin (OPN) is expressed in a range of immune cells, including macrophages, neutrophils, dendritic cells, and Tand B cells, with varying kinetics. OPN is reported to act as an immune modulator in a variety of manners. Firstly, it has chemitactic properties, which promote cell recruitment to inflammatory sites. It also functions as an adhesion protein, involved in cellattachment and wound healing In addition, OPN mediates cell activation and cytokine production, as well as promoting cell survival by regulating apoptosis"
     

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