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XMRV: exogenous and/or endogenous?

Discussion in 'XMRV Research and Replication Studies' started by fresh_eyes, Nov 12, 2009.

  1. fresh_eyes

    fresh_eyes happy to be here

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    This is great, gracenote! I hadn't seen it before.
  2. Alice Band

    Alice Band PWME - ME by Ramsay

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    In 12 of these cases the CFS relatives were maternal, and in 10 they were paternal

    from

    Underhill RA, O’Gorman R. Prevalence of Chronic Fatigue Syndrome within families of CFS patients. J CFS 2006; 13(1):3-13.

    Also from the same document (sorry it has lost the formatting)

    Family members with CFS n/total % Family members with CFS mean (95% CI) p-value †
    Spouses/partners 6 /186 3.2 (0.7 to 5.8) < 0.001
    Offspring 12/235 5.1 (2.3 to 7.9) < 0.001
    Parents & siblings 8/730 1.1 (0.34 to 1.84) < 0.02
    All 1st degree relatives 20/965 2.1(1.2 to 3.0) < 0.001
    2nd & 3rd degree relatives 24/3216 0.8 (0.45 to 1.05) < 0.02
    All blood relatives 44/4181 1.1 (0.75 to 1.3) < 0.001

    Maybe someone else can extrapolate from the data in that study. I think it came from Dr Jason. There are some interesting graphs

    I don't know (for instance) what the significance of this is (bit it is unusual so I will mention it), the graph shows % of children with CFS and is split into male and female (approx 4% male and approx 6% female), now that is very different to the % male and female reported ratio we see in non-obviously parent CFS isn't that?

    The graph also shows the data for male and female relatives 1st and 2nd & 3rd degree and the male female split is again a lot more even than I would have thought but not as close as the "offspring". It's hard to tell on the chart as the data is too small for the axis.
  3. fresh_eyes

    fresh_eyes happy to be here

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    Thanks for posting this, Alice Band - do we know what criteria were used to define CFS in that study?
  4. Alice Band

    Alice Band PWME - ME by Ramsay

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    CFS under the CDC 1994 revised case definition

    The subjects came from the New Jersey CFS Association

    Interestingly, it also says (about the CDC CFS group)

    "
    Significant differences were seen between the prevalence of CFS in all groups of family members relative to that in the Chicago community sample reported by Jason et al
    "

    Also

    as the proportion of female and male patients with CFS relatives was found to be similar (18% vs. 19%).

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