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XMRV - Current Research Program

Discussion in 'XMRV Research and Replication Studies' started by VillageLife, Jun 3, 2010.

  1. VillageLife

    VillageLife Senior Member

    United Kingdom
    I found this information on the WPI website, So Everyone please sleep well tonight, we're being looked after! :Retro smile:

    Current Research Program

    Role of Chronic Inflammatory and Immune Stimulation by Active Herpesvirus Infection in the Development of Immune Dysfunction in CFS
    Studies of immune abnormalities in this CFS cohort will involve phenotypic analysis of NK, DC, and T cell populations. States of activation and differentiation will be studied to determine whether the cells are immune activators or suppressors due to response to infection. The goal is to understand the imbalance in the immune system that leads to unregulated virus expression.
    Collaborators: Francis Ruscetti, PhD, NIC, Dennis Taub PhD, NIA (INIP Research Award)

    Novel Viruses/Co-infections in Subgroups of CFS
    A Virus DNA Microarray (Virochip) was used to screen a cohort of CFS with Immunological defects and increased incidence of Mantle cell lymphoma (MCL).
    Collaborators: Francis Ruscetti, PhD, Cancer Inflammation Program, NCI

    Role of the Interferon/RNaseL Antiviral Pathway in CFS
    The goal of this study is to characterize defects in the Interferon/RNaseL antiviral pathway which result in viral persistence.
    Collaborators: Robert Silverman, PhD, Cleveland Clinic

    Role of Inflammatory Cytokines and Chemokines in CFS
    The purpose of this study is to identify and develop the serum biomarker patterns of cytokine and chemokines, which correlate with clinical disease and can be used to monitor intervention.
    Collaborators: Dennis D. Taub, PhD, NIA

    Host Susceptibility in CFS
    The goal of this study is to elucidate genetic factors of susceptibility and the dysregulation of the host defense system in order to develop biomarkers for diagnostic development and thus predict response to immune modulating therapy and vaccines.
    Collaborators: Jonathan R. Kerr, MD, PhD, St. Georges University, London UK,
    Mary Carrington, PhD, NCI, Mike Dean, PhD, NCI

    Enumeration and Function of Natural Killer (NK) Cells in CFS
    The purpose of this project is to develop improved NK diagnostic tests for both the number and function of NK cells.
    Collaborators Doug Redelman, PhD, UNR, Dept. of Microbiology & Immunology

    Epidemiologic Evaluation of Lymphoma and Cancer Incidence in Nevada CFS Cohort
    The goal of this study is to determine if a possible cancer cluster exists in the cohort of Nevada CFS patients.
    Collaborators: Paul Levine, MD, George Washington University

    Study of Clonal T Cell Receptor-gamma Rearrangements in Nevada CFS Cohort
    The purpose of this study is to determine the significance of clonal T cell receptor-gamma rearrangements in the pathogenesis of CFS.
    Collaborators: Dorothy Hudig, PhD, UNR, Dept. of Microbiology & Immunology

    Development of a Whole Genome Transcriptome Assay for HHV6
    The goal is to develop a whole genome transcriptome assay for HHV6 and a sub array for HHV6A specific detection to be used as a diagnostic tool or research tool to understand the viral life cycle in disease.
    Collaborators: Rachel Bagni, PhD, Applied Technology Program, NCI

    HHV6 Latency in CFS

    The goal of this study is to understand the role of HHV6A latency in bone marrow hematopoietic stem cells in the pathogenesis of CFS.
    Collaborators: Stephen St. Joer, PhD
    Marianna Bego, PhD, UNR, Dept. of Microbiology & Immunology
  2. V99

    V99 *****

    Thanks Villagelife.
    It all sounds good, and look at who they are still working with. We climbing out of that gutter people. :victory:
  3. Robyn

    Robyn *****

  4. Kati

    Kati Patient in training

    This research program page has been there for months, nothing new. I would believe WPI would release the news if they got some grant money, that would be an event by itself.
  5. Robyn

    Robyn *****

  6. VillageLife

    VillageLife Senior Member

    United Kingdom
    I posted it on here in case people had missed it!
  7. usedtobeperkytina

    usedtobeperkytina Senior Member

    Clay, Alabama
    No wonder they need more money.

    That's a lot of research. Curious nothing into Autism or Fibromyalgia.

  8. glenp

    glenp "and this too shall pass"

    Vancouver Canada suburbs
    Villagelife, thank you for posting this, I hadn't seen it


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