After acute viral onset ME in the eighties, including being bedbound for many years, I had a period of what I thought was 90% recovery but turned out to be remission that lasted about seven years or so. Now I am housebound again after a series of mini-relapses that turned into a big relapse. :worried: I don't think this is uncommon. If XMRV = ME, how can people get very substantial remissions after years of severe illness? Is it plausible that the body could drive a retrovirus into even partial submission on its own? I received no treatment, just rested a lot. Sorry if this has been discussed elsewhere! The XMRV topic has got very big!