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XMRV & Blood Supply Webinar Tuesday, Mar 29

Discussion in 'Media, Interviews, Blogs, Talks, Events about XMRV' started by ahimsa, Mar 6, 2011.

  1. ahimsa

    ahimsa Senior Member

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    I saw the following announcement on the ProHealth web site (see http://www.prohealth.com/library/showarticle.cfm?libid=15966 ) but didn't find it on these forums. I did a search but might have missed it. Moderators, please delete this message if it is a duplicate. Thanks!

  2. Cort

    Cort Phoenix Rising Founder

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    that's great Ahimsa - I missed this completely. This will be Dr. Mikovits first presentation since CROI and our first look at Dr. Lipkin......Thanks!
  3. Otis

    Otis Señor Mumbler

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  4. Lynn

    Lynn Senior Member

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    Thanks, Otis. I am all signed up! Hopefully this will counter the arguments at CROI.

    Lynn
  5. SpecialK82

    SpecialK82 Senior Member

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    Unless it has been canceled, Mikovits is scheduled to speak in Alberta, Canada on Mar 17, "Strategies for Detecting XMRV infection in Clinical samples"
  6. Persimmon

    Persimmon Senior Member

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    Mikovits & Ruscetti appear to have just presented at a Hemispherx conference:

    http://www.globenewswire.com/newsroom/news.html?d=215608
  7. Hope123

    Hope123 Senior Member

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    Thanks for posting!

    NYAS is a prestigious place to present.
  8. lansbergen

    lansbergen Senior Member

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    http://www.nyas.org/Events/Detail.aspx?cid=0918b8d8-9a46-4334-b194-23ade9c2a7aa

    Disease Associations of XMRV and MLV-Related Viruses

    Judy A. Mikovits, PhD, Whittemore Peterson Institute for Neuro-Immune Disease

    A new human retrovirus first associated with QQ variant RNaseL a gene in the hereditary prostate cancer gene locus, in prostate cancer in 2006. Detection of integration sites in unmanipulated prostate tissue; demonstration of neutralizing antibody and in situ hybridization for XMRV, supports XMRV as a human retroviral infection associated with prostate cancer. Although in the absence of direct sequencing it cannot be rule out the reactivity can be to related MLV viruses.

    In 2009 using a classical virology approach of viral isolation and transmission, electron micropscopy, serology and PCR, Lombardi et al demonstrated the first isolation of XMRV from blood from patients with chronic fatigue syndrome (CFS) predominately from the west coast of the United States. In 2010, Lo et al. extended these studies by detecting nucleic acids of MLV-related variants in the peripheral blood mononuclear cells of CFS from the northeastern United States suggesting additional strains capable of infecting humans exist.

    In a study of 300 CFS patients, 13 developed lymphoproliferative disorders. Of those tested, 11/11 were positive for XMRV and 9/9 positive for clonalTCR gamma rearrangements. Spontaneous development of four immortalized B cells lines occurred during culture of cells from CFS patients. Three developed from B cells isolated from the peripheral blood (two of whom had B cell lymphoma) and one from a bone marrow biopsy.

    The B cell lines have a mature CD20+, CD23+ phenotype and produce infectious XMRV. Virus production occurred despite extensive hypermutation of the proviruses in these cells by APOBEC3G.
    Therefore, XMRV infection may accelerate the development of B cell malignancies by either indirect chronic stimulation of the immune system and/or by direct infection of the B-cell lineage. Since viral load in peripheral blood is low, these data suggest that B cells in tissues such as spleen and lymph nodes could be an in vivo reservoir for XMRV.

    We have also identified an inflammatory cytokine and chemokine signature that distinguishes XMRV infected CFS patients from healthy controls with 94% sensitivity and specificity Monitoring immune dysfunction affords the opportunity to begin to understand the pathogenesis of XMRVs. In addition to these data, recent advances in developing tests for detection and characterization of XMRV–variants will be also be discussed
  9. jace

    jace Off the fence

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    Abstracts are up for the 29/3 talk

  10. Cort

    Cort Phoenix Rising Founder

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    This is a biggie because it suggests that XMRV can evade APOBEC editing in B-cells! B-cells therefore could be a reservoir - which is so intriguing given EBV infection in B-cells and the cancer mentioned above. Interesting that it may replicate in just the cells that are so problematic in CFS! :cool:

    If XMRV can just get validated it has some really ntriguing connections.....there are the nerve cells Dusty Miller is working on as well...
  11. Cort

    Cort Phoenix Rising Founder

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    Right - Thanks!
  12. LaurieM

    LaurieM

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    I have been mulling over the following part of Judy Mikovits's abstract for this up coming event since reading it a week ago (unfortunately I have been too ill to put fingers to keyboard up until now):

    Do I remember correctly (or maybe it was just a suggestion), that Judy Mikovits was going to test blinded samples from other labs to determine if her processes worked (ie not contamination etc). If I did read it, then it would have been on these boards; someone please correct me if I'm wrong.

    Assuming this is the case, then is it possible that Judy Mikovits is about to 'drop the world a note' that she has determine 94% of the samples correctly. If so, then this would be a massive kick in the teeth to the naysayers, as it would imply that XMRV is linked to ME/CFS, otherwise how would her testing have been 94% accurate?

    Another assumption could be that she is 100% accurate - the other 6% may be healthy XMRV carriers - which kind of fits in with previous figures!

    I actually hate making assumptions, but I had to get this off my mind and get some feedback.

    I look forward to the event and what Judy and the other speakers have to say.

    BTW if the naysayers say that Judy Mikovits just got lucky with her 94%, then she might as well give up and make some money in Vegas :rolleyes:

    Laurence :In bed:
  13. currer

    currer Senior Member

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    You could be right, Laurie. This looks like it could be the in-depth research we have been deprived of during all those other contamination/ PCR studies.
  14. LaurelW

    LaurelW Senior Member

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    Can anyone help me figure out how to register for free? I've heard that some people have been able to. Whenever I go to the registration page, it wants either $30 for regular people or $15 for students. Would rather not spend that money if I don't have to.
  15. shannah

    shannah Senior Member

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    Hm-m-m Laurel. When I registered when it was first announced, it was free.

    I just went to the website now and there seems to be 2 options.

    Register Now - clicking on this link presents a charge
    and
    Register for Webinar - this link has a charge $0.00

    so try registering following the second one. Hopefully that will work for you.


    http://www.nyas.org/Events/Detail.aspx?cid=0918b8d8-9a46-4334-b194-23ade9c2a7aa
  16. LaurelW

    LaurelW Senior Member

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    Thanks Shannah. That's so weird, I went to the exact same page earlier and there was a fee. But just now I registered for nothing. (theme from Twilight Zone)
  17. Sherby

    Sherby Sherby

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  18. Wonko

    Wonko Senior Member

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    possibly - yesterday following the above link it was $0 - today it's $30
  19. Jim

    Jim Senior Member

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    got it. thanks.
  20. hope

    hope

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    duplicate post

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