Hi, I was wondering if any one has any information on how XMRV effects the immune system or is it still to early to tell. A lot of what i have read about CFS would suggest that people have an alteration in there immune response and most people seem to have an underactive immune system resulting them getting sick all the time and catching every flu bug etc. Is it possible that the XMRV virus could alter the immune system the other way ie autoimmunity ?. I have had all the sore throats , herpes reactivation etc that other ME patients have but my immune sytem seems to kill everything in sight including my thyroid, resulting in normal TSH levels but very high Thyroid antibodies. I had my R-Nase L tested about 8 years ago by RedLabs in Belgium and it seemed to be normal. Anyone have any thoughts on this or similarly have an overactive immune system. I am presuming that an altered immune state would not just suggest that the immune system is weak but altered so that it cant identify the virus and hence may be targeting other systems instead of the virus, is it also possible that the alteraton to the immune system could result in the immune system not being able to switch itself off ? Sorry for the spelling my brain is like a paw paw thank you.