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XMRV and Public Health: The Retroviral Genome Is Not a Suitable Template for Diagnostic PCR

Discussion in 'XMRV Research and Replication Studies' started by AndyPR, Jun 10, 2017.

  1. AndyPR

    AndyPR Senior Member

    https://www.ncbi.nlm.nih.gov/pubmed/28589117

    Open access PDF - https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5439170/pdf/fpubh-05-00108.pdf
    And online version - http://journal.frontiersin.org/article/10.3389/fpubh.2017.00108/full
     
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  2. Esther12

    Esther12 Senior Member

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    In some ways I'm surprised that papers are still being published on this. Maybe it took them a long time to write up and get published?
     
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  3. AndyPR

    AndyPR Senior Member

    I just spotted it being linked elsewhere so have no extra info unfortunately, other than what is on the paper itself.
     
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  4. Valentijn

    Valentijn Senior Member

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    This seems to be more about the genetic aspect of XMRV, though the ME/CFS controversy is what presented them with an interesting puzzle. From what I can understand after a quick skim, PCR techniques present a problem here because segments of the host's own DNA (possibly of ancient retroviral origins) can end up looking very similar to the sequences used to identify XMRV.
     
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