10 January 2012: Pubmed: http://www.ncbi.nlm.nih.gov/pubmed/22231291 XMRV and prostate cancer-a 'final' perspective. Sfanos KS, Aloia AL, De Marzo AM, Rein A. Source: Department of Pathology, Johns Hopkins University School of Medicine, Baltimore, MD 21231, USA. Abstract XMRV was first described in 2006, when it was identified in samples isolated from prostate cancer tissues. However, studies have since shown that XMRV arose in the laboratory and was formed by genetic recombination between two viral genomes carried in the germline DNA of mice used during serial transplantation of the CWR22 prostate cancer xenograft. These new findings strongly imply that XMRV does not circulate in humans, but is only present in the laboratory. Thus, there is no reason to believe that it has any role in the etiology of prostate cancer or other diseases.' This is a paper published in Nature Reviews Urology: http://www.nature.com/nrurol/journal/vaop/ncurrent/full/nrurol.2011.225.html Just reading through it now. Thanks Jemal for posting the link on another thread: http://forums.phoenixrising.me/showthread.php?15525-New-Paper-by-Dr-Ruscetti&p=232893#post232893 Several have been debating the relevance of prostate cancer and XMRV and I dare say there will be more considerations such as this opinion piece. Edit: 'Introduction: Several classes of viruses, including retroviruses, are known to cause cancer in humans and animals. The possibility that additional types of cancer could be caused by as yet unidentified viruses holds great appeal. However, the attractiveness of this hypothesis has also led to cancer causation being mistakenly attributed to viruses.1,2 It has long been postulated that viruses could have a role in prostate cancer etiology, and reports of viruses in association with prostate cancer date back over 30 years. Thus far, however, no virus has been causally linked to prostate cancer. The latest entry into this catalog is xenotropic murine leukemia virus-related virus (XMRV). This Perspectives article will critically evaluate studies that seemed to identify XMRV in prostate cancer samples, address the known sources of false-positive results in XMRV assays, and describe and explain in depth the findings and the implications of a study that showed that XMRV was formed by a rare recombination event in the laboratory. Thus, we will chart the rise and fall of XMRV from its initial detection in 2006, via claims of its role in prostate cancer, to the 2011 report of its recombinant origin.' Cool.... Edit: Link to MECFSForums thread:http://www.mecfsforums.com/index.php/topic,11109.0.html I should say I suppose that this review includes those studies pertaining to an association of XMRV/MLVs in Chronic Fatigue Syndrome. Am still reading but so far it is proving quite comprehensive.