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XMRV abstracts from 15th International Conference on Human Retroviruses

Discussion in 'XMRV Research and Replication Studies' started by kday, May 15, 2011.

  1. kday

    kday Senior Member

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    Exacerbated signs of an immunosuppressive AIDS-like disease in macaques infected with multiple retroviruses
    http://www.retrovirology.com/content/8/S1/A207

    Restricted infection of xenotropic murine leukemia virus-related virus in human lymphoid tissue
    http://www.retrovirology.com/content/8/S1/A208

    Heme oxygenase-1 activation inhibits XMRV pathogenesis and carcinogenesis in prostate cancer cells
    http://www.retrovirology.com/content/8/S1/A218

    XMRV replicates preferentially in mucosal sites in vivo: Relevance to XMRV transmission?
    http://www.retrovirology.com/content/8/S1/A219

    A prototype RT-PCR assay for detection of XMRV in multiple human sample types
    http://www.retrovirology.com/content/8/S1/A220

    Immune correlates of XMRV infection (Mikovits)
    http://www.retrovirology.com/content/8/S1/A221

    Prevalence of XMRV in blood donors, HTLV and HIV cohorts
    http://www.retrovirology.com/content/8/S1/A222

    The effects of XMRV gene expression on the mouse prostate
    http://www.retrovirology.com/content/8/S1/A223

    XMRV: usage of receptors and potential co-receptors
    http://www.retrovirology.com/content/8/S1/A224

    Cell line tropism and replication of XMRV
    http://www.retrovirology.com/content/8/S1/A225

    Independent evolution of intracellular transposons from exogenous IAP-related retroviruses in a broad range of mammalian species
    http://www.retrovirology.com/content/8/S1/A226

    Structure of the xenotropic murine leukaemia virus-related virus matrix protein
    http://www.retrovirology.com/content/8/S1/A227

    Development of XMRV producing B Cell lines from lymphomas from patients with Chronic Fatigue Syndrome (Mikovits)
    http://www.retrovirology.com/content/8/S1/A230

    Multi-laboratory evaluations of XMRV nucleic acid detection assays (Mikovits, Coffin, Ruscetti, Switzer, etc)
    http://www.retrovirology.com/content/8/S1/A231

    Serologic and PCR testing of persons with chronic fatigue syndrome in the United States shows no association with xenotropic or polytropic murine leukemia virus-related virus (Switzer)
    http://www.retrovirology.com/content/8/S1/A232

    Detection of MLV-like gag sequences in blood samples from a New York state CFS cohort
    http://www.retrovirology.com/content/8/S1/A234

    Murine leukemia viruses (MuLV) and Xenotropic MuLV-related viruses exhibit inter-tropic complex recombination patterns
    http://www.retrovirology.com/content/8/S1/A235

    In vitro assembly of xenotropic murine leukemia virus-related virus CA-NC protein
    http://www.retrovirology.com/content/8/S1/A236

    XMRV infection in human diseases
    http://www.retrovirology.com/content/8/S1/A238

    Human infection or lab artifact: will the real XMRV please stand up? (Silverman)
    http://www.retrovirology.com/content/8/S1/A241

    --------------

    Unfortunately, there is no abstracts to these "abstracts" but I can only guess from the titles that they are starting to take XMRV more seriously.
     
  2. Sasha

    Sasha Fine, thank you

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    Thanks for posting, kday - I see that meeting is happening on June 5-8 (in Belgium) so not long to go.
     
  3. Sasha

    Sasha Fine, thank you

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    I wonder if this is old news?:

     
  4. Esther12

    Esther12 Senior Member

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    Thanks for this. Great to have them all laid out for that.

    It will be interesting to get more info on all these studies.
     
  5. Esther12

    Esther12 Senior Member

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    Have we got results from that then? I can't remember the names of all the different XMRV studies now.
     
  6. Bob

    Bob

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    So it's definitely mouse contamination then?
     
  7. omerbasket

    omerbasket Senior Member

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    It probably is. Dr. Hanson tested 10 ME/CFS patients that are severely ill, 10 ME/CFS patients that think that they have recovered (but questionnaires indicate that they are not fully recovered) and 20 healthy controls - and as of last December we know that she found PMRVs in 7 out of the 10 severly ill, 7 out of the 10 "recovered" and 4 out of the 20 controls.
    She thinks that the explanation for the pretty large number of infected controls can be one or both of the following reasons:
    1) All of the study participants came from the same area - Lyndonville New-York, an area of a known ME/CFS outbreak back in the 80's, and I think that at least some of the controls are in contact with ME/CFS patients - like, they are friends of them and stuff like that.
    2) Her study is small - and had it been larger it's possible that the percentage of infected individuals would have decreased.

    She did say in December that she didn't yet finish her study - I wonder if she has new things to tell us.
     
  8. kday

    kday Senior Member

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    Bob - it seems to look like that is the case. In fact, we should all just move on and XMRV should just be left behind. ;)
     
  9. Jemal

    Jemal Senior Member

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    Oh man, another day to look forward too. I can spot at least one positive paper, probably more. I feel like a kid in the candy store. It's an avalanche of research...
    Also: Human infection or lab artifact: will the real XMRV please stand up?
    Is that title hilarious or what?

    The day after this conference there will be another event in Brussels, called "XMRV (a novel retrovirus) is here to stay.":
    http://forums.phoenixrising.me/show...retrovirus-is-here-to-stay-(event-in-Brussels

    Hopefully something positive will come from this and I am not setting myself up for disappointment again.
     
  10. Jemal

    Jemal Senior Member

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    This one is also by Switzer by the way
    Murine leukemia viruses (MuLV) and Xenotropic MuLV-related viruses exhibit inter-tropic complex recombination patterns
     
  11. Bob

    Bob

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    I'm hoping that there might be a positive announcement at the Invest in ME conference as well.
     
  12. Bob

    Bob

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    Yes, I agree, there is clearly no XMRV... We should all just move on now... :rolleyes:
     
  13. Bob

    Bob

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    Interesting that Switzer should bother publishing this research, seeing as he has already proved that he cannot detect XMRV in the blood of XMRV-positive prostate cancer patients. I wonder what evidence he has to suggest that he is able detect XMRV in the blood of other XMRV-positive patients, using the same failed methodology.
     
  14. toddm1960

    toddm1960 Senior Member

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    XMRV has been dead for a awhile now, why is there even a tread about it?
     
  15. kday

    kday Senior Member

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    If they are in order by abstracts, this looks like it will be the last presentation by Silverman. And yes, that's my favorite title.
     
  16. beike

    beike

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    The thread is here because a retroviral infection explains CFS on so many levels:

    Just look at the first title of the first article "Exacerbated signs of an immunosuppressive AIDS-like disease in macaques infected with multiple retroviruses." Are we really going to assume that enough variation exists between us and macaques that this virus is completely innocuous, or that is it simply a contaminant? That makes no sense. If the virus can infect human prostate cells, there is a very good chance that it has the same effect on humans. Also, XMRV infects mucosal tissue which explains a lot in regards to the intestinal issues that patients with cfs experience. We even have an entire section in this forum dedicated to intestinal issue related to cfs. To further support the validity of XMRV infectivity, a distinct inflammatory cytokine profile has been established for patients that are XMRV infected. When treated with ARVs, this profile begins to reflect a healthier pattern. Families with an XMRV infected individual are more likely to have family members infected as well.

    More needs to be done to understand how XMRV replicates: what is the life cycle of XMRV, are there ways in which it operates that are different from other viruses, which cells are reservoirs for XMRV, how do these cells react to XMRV infection and what are the results, how is XMRV modified once it infects a cell, what are the roles of confections in perpetuating disease, what kind of genetic sequence variation can occur when one is infected, How would this sequence variation affect PCR test results

    XMRV is not a dead end. It marks the beginning of a new direction in medicine that attempts to understand the greater role of retroviruses in human disease. When you think about it, it only makes sense that retroviruses play a bigger role in disease. Human DNA is chalk full of retroviral sequences that are a product of an evolutionary arms race between host and retrovirus. To assume that there are very few human retroviruses and they only produce a handful of diseases contradicts the history of retroviral infections we can see in the DNA of every human being.
     
  17. Jemal

    Jemal Senior Member

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    I think you missed the sarcasm beike :D
    Good defense of XMRV research though...
     
  18. heapsreal

    heapsreal iherb 10% discount code OPA989,

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    isnt the treatment for xmrv the antiretroviral called exercise and being positive also prozac.
    Just more sarcasm, lol.
     
  19. Jemal

    Jemal Senior Member

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    Excercise always helps ;)
    Nowadays I am huffing and puffing after taking one stairway...
     
  20. Bob

    Bob

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    You need to keep pushing your activity boundaries Jemal...
    If you're only huffing and puffing after one stairway, you need to increase it to two!
    Then keep increasing the number of stairways until you collapse in exhaustion and experience a permanent relapse.
    And then, if you use the excuse of a relapse in order to avoid activity, maybe you should seriously consider your motivation and your commitment to getting better!

    (Sorry, more sarcasm - i'm in that sort of mood today!)
     

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