I.ve replied undecided for a number of reasons 1. Like dreambirdie i am very sensitive to supplements and medications. Steroids put me in bed with pneumonia for a year and SSRI'S took away my sanity for nearly 2. I have also reacted strongly to normal supplements including those not known to have side effects. 2.Like Sallyblooms i have been improving gradually and slowly with natural approaches. Today i was able to have a walk without my wheelchair and paly a game sitting up in a chair with my daughter for over an hour with no ill effects at all. Last year i coulodnt do either of these things. 3.I am concerned about the effect on my immune system. Although i think my illness does fit with an autoimmune theory (i have recently developed swollen joints and joint pain) i also have a fibrotic band in my lung and must avoid infections at all costs. Its likely that although i meet ALL criteria for M.E this one thing would rule me out. I'm all for waiting to see iof a more targeted drug comes along, and i know many here think this will happen if the Fluge and Mella trials go well, but dont forget that these type of drugs are allready used in Lupus, rheumatoid arthritis, MS etc and no one is rushing to find them a safer drug. I'm not holding my breath. On the other hand when i saw the Fluge and Mellas presentation on the DVD of the Invest In ME conference i literally cried and wanted to get straight on a plane to Norway! Justy.