A New Decade of ME Research: The 11th Invest in ME International ME Conference 2016
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Would someone mind helping methylation and detox SNP analysis

Discussion in 'Genetic Testing and SNPs' started by Nicole888, Feb 5, 2017.

  1. Nicole888

    Nicole888

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    Hi
    I am in Australia and am hoping someone would give some insight to my methylation and detox report as I'm not sure about any of it. Sorry if the list is long but not sure which are relevant. Have had CFS since 2000 and now autoimmune issues are starting :( I dont have regular internet as i am living in a tent ATM.

    Thank you
    Nicole

    METHYLATION

    MTRR rs1801394 G GG +/+
    MTRR rs1801394 G GG +/+
    MTRR rs326121 T TT +/+
    MTRR rs3776455 T TT +/+
    MTRR rs8659 A AA +/+
    SOD2 rs2758331 A AA +/+
    SOD2 rs4880 G GG +/+
    SOD2 rs2758339 C CC +/+
    SOD3 rs2855262 C CC +/+
    SOD3 rs2536512 A AA +/+
    ACE DEL16 rs4343 G GG +/+
    BHMT rs3733890 A AA +/+
    BHMT rs492842 C CC +/+
    MAOB rs1799836 C CC +/+
    ACAT2 rs25683 G GG +/+
    ACAT2 rs3465 A AA +/+
    ACAT2 rs3798211 C CC +/+
    GAMT rs55776826 T TT +/+
    PEMT rs4646406 A AA +/+
    GAD1 rs3791878 T TT +/+

    CBS rs2851391 T CT +/-
    CBS rs4920037 A AG +/-
    CBS A360A rs1801181 A AG +/-
    CBS C699T rs234706 A AG +/-
    COMT rs6269 G AG +/-
    COMT H62H rs4633 T CT +/-
    COMT V158M rs4680 A AG +/-
    DAO rs3741775 C AC +/-
    MAOA rs6323 G GT +/-
    MTHFR A1298C rs1801131 G GT +/-
    MTHFR rs1476413 T CT +/-
    MTHFR rs4846049 T GT +/-
    MTRR A664A rs1802059 A AG +/-
    NOS2 rs2248814 A AG +/-
    NOS2 rs2274894 T GT +/-
    NOS2 rs2297518 A AG +/-
    NOS3 rs1800779 G AG +/-
    NOS3 rs1800783 A AT +/-
    NOS3 rs3918188 A AC +/-
    VDR BSM rs1544410 T CT +/-
    VDR TAQ rs731236 G AG +/-
    ACAT1 rs10890819 T CT +/-
    ACAT1 rs2280332 C AC +/-

    AGT rs699 A AG +/-
    C1ORF167 rs4846048 G AG +/-
    CLCN6 rs3737964 T CT +/-
    FOLR2 rs651933 G AG +/-
    GAD1 rs3791851 C CT +/-
    GAD1 rs701492 T CT +/-
    GAD1 rs769407 C CG +/-
    GAMT rs17851582 A AG +/-
    MTHFD1 rs1076991 T CT +/-
    MTHFD1 rs2236225 A AG +/-
    MTHFD1L rs6922269 A AG +/-
    MTHFS rs6495446 T CT +/-

    DETOX

    CYP2D6 S486T rs1135840 GG +/+
    CYP1B1 R48G rs10012 -- no call

    CYP1A2 164A>C rs762551 AC +/-
    CYP1B1 L432V rs1056836 CG +/-
    CYP1B1 R48G rs10012 -- no call
    CYP2A6*2 1799T>A rs1801272 AT +/-
    CYP2C9*3 A1075C rs1057910 AC +/-
    CYP2D6 100C>T rs1065852 AG +/-
    CYP2D6 2850C>T rs16947 AG +/-
    NAT2 I114T rs1801280 CT +/-
    NAT2 K268R rs1208 AG +/-
    GSTT1 Absent
     
    Last edited: Feb 6, 2017
    Sherpa likes this.
  2. Sherpa

    Sherpa Ex-workaholic adrenaline junkie

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    Hi Nicole,

    These are the ones I am familiar with that I consider relevant:

    1.) MTRR A66G rs1801394 G GG +/+


    is a mutation with the gene involved in recycling Vitamin B12. If you have CFS and this mutation, there's a chance you might be functionally low in B12. You might want to consider highly absorb able B12, such as Australia-based B12Oils. I have this mutation and the Adenosylcobalmin / Methylcobalmin mixture is what I use. Sublingual B12 tablets are better than nothing.


    2.) MTHFR

    it looks like you are heterogeneous (half-mutated) for A1298C... but I don't see info for the "major" MTHFR gene dysfunction which is C677T. do you have this info?

    You may have reduced functionally in covering folate in food into methylfolate. I have reduced functionality and it caused me severe depression and chronic inflammation until I fixed it.

    You MIGHT benefit from taking methylfolate (start small, like 100mcg, and increase slowly). If methylfolate helps consider an all-in-one methylation formula like MethylGuard or Methy B Complete. These have methylfolate, TMG, B2, B6, B12... everything you need to support our methylation cycle.


    2.) SOD2 A16V rs4880 G GG +/+

    Having the SOD2 mutation means there's a chance you might be lower than average in mitochondrial antioxidant superoxide dismutase. This can make you more susceptible to aging, chronic fatigue, and noise related hearing loss. If you want to address it, a supplement called MitoQ may help some people with this mutation. It's expensive but it gave me a lot of energy. I recovered so I no longer take it.


    Hope this helps! Much love and best of luck with your health and living situation. :heart:
     
    Last edited: Feb 6, 2017
  3. Valentijn

    Valentijn Senior Member

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    Average MTHFR functionality in the general population is about 70% of optimal. A1298C +/- would only be about a 17% reduction in MTHFR functionality, so it would be better than average to only have that mutation.
     
  4. caledonia

    caledonia

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    Cincinnati, OH, USA
    Look in my signature link for the SNPs Interpretation Guide. You can run your 23andme raw data through geneticgenie.org to pull out the relevant SNPs.

    However, at this time, I think Ben Lynch's Strategene interpretation may be superior for the methylation section. The detox section is still ok.

    I also have links to Strategene and geneticgenie on the page.
     
    Sherpa likes this.
  5. vortex

    vortex Senior Member

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    Did you look up your 677t status ? I dont see it, also known as rs1801133
     
  6. Nicole888

    Nicole888

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    Hi
    The 677t is -/-.
    Thank you for your replies. I will look at the links and may have some other questions.
    Nicole
     
  7. WendyM

    WendyM

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    Hello Nicole,

    I have CFS and also live in Australia. I would really like to have contact with you ..... could you email me to

    wendy.murray18@gmail.com. .. and let me know where you are and how I could get in touch with you.

    I do hope you find this and get in touch.

    Wendy
     
  8. Chans

    Chans

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    Is there a way to test without an expensive genetic test when shmt1 is a "no call" on 23andme?

     
  9. Valentijn

    Valentijn Senior Member

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    I wouldn't bother. It probably doesn't do anything :p
     
    Chans likes this.
  10. caledonia

    caledonia

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    Do you mean a test for SHMT1? If so, there is nothing that I know of.

    Ben Lynch doesn't have SHMT on the Strategene test - it looks like MTHFD may be a more important actor in that area of the cycle.
     
  11. Paralee

    Paralee Senior Member

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    Well, that's great. I have all variants in those 5 snps that self hacked link listed. So I have high oxidative stress? I need to what? Up my SOD2 or take it down? I have too much or too little?

    I need to increase it, right?

    (I tried PQQ a while back and felt weird on it)
     
  12. Valentijn

    Valentijn Senior Member

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    Self-hacked isn't a reputable source. It's necessary to look up the SNPs involved to see if research shows that the really have an impact, and how large any impact is.
     
    Paralee likes this.

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