Hi guys, this is my first time posting here & sorry in advance if it's very long and quite scattered. I'm actually going to paste what I posted at mthfr.net since I'm in so much pain today. You can read his reply here:Dr. Ben's Reply I've been reading the methylation forum a bit but it's so over my head and I can't seem to concentrate much anyway. I've been taking Metanx since Jan 16th but have bronchitis and am back to severe pain & fatigue (bones hurt, burning muscles like lactic acid build up, neuropathy, muscle cramps, joint aches...). I can't live like this, you guys. I have to take care of my son and NOBODY understands me or really believes there's anything wrong. My family is like, "maybe if you exercised more, you wouldn't feel so crappy." YEAH, when I exercise, it'll wipe me out for a day or two! Goodness, I don't know what to do. I'm so so overwhelmed, depressed, feel dull and lifeless and just want to die at this point. Life is not worth living if it's like this. Anyway, enough with my whining. Dr. Ben doesn't think my particular MTHFR mutation is that severe. Perhaps it's not, but Metanx definitely changed something and I felt remarkably different within 2-3 weeks of taking it. However, I've gotten sick & am back to severe pain and fatigue. I'm not sure what to think about that. Does anyone have any advice or tips? I'm so very depressed every day and extremely bitter that I can't live my life and give my son the mommy he needs. Anything at all would be helpful. Thank you in advance. ETA - Had my vitB12 levels checked and they were normal. My D levels are currently on the low end of normal but I supplement with 5000iu of D3 everyday.